Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 209-378-3 | CAS number: 574-93-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979-11-01 to1980-08-21
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Data from reliable source, non GLP, testing above water solubility
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)
- Principles of method if other than guideline:
- "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances"
- GLP compliance:
- no
- Specific details on test material used for the study:
- Purity: >= 99 %
- Radiolabelling:
- not specified
- Vehicle:
- yes
- Details on preparation of test solutions, spiked fish food or sediment:
- Chemical name of vehicle: Crystal sugar, HCO-40
- Concentration of vehicle: 1st Concentration area: Crystal sugar 250 ppb(w/v), HCO-40 250 ppb(w/v), 2nd Concentration area: Crystal sugar 25 ppb(w/v), HCO-40 25 ppb(w/v) - Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Common name: Common carp
- Source: obtained from a commercial fish farm in Japan
- Length at study initiation (lenght definition, mean, range and SD): 10 cm
- Weight at study initiation (mean and range, SD): 30 g
- Lipid content of fish: 2 - 6 %
ACCLIMATION
- Acclimation conditions (same as test or not): flow through at 25 ± 2 °C
- Type and amount of food: obtained from a commercial fish farm in Japan at a rate of 2% of the total body weight
- Feeding frequency: daily, no feeding at the day of sampling - Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 6 wk
- Test temperature:
- 25 ± 2 °C
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: glass tanks, volum = 100 L
- Renewal rate of test solution (frequency/flow rate): 200 - 800 ml/min
- No. of vessels per concentration (replicates): 15 - 20
- No. of vessels per control / vehicle control (replicates): 15 - 20
TEST MEDIUM / WATER PARAMETERS
- Holding medium different from test medium: no
- Intervals of water quality measurement: twice a week - Nominal and measured concentrations:
- 0.01 mg/l and 0.1 mg/l
- Key result
- Type:
- BCF
- Value:
- >= 2.1 - <= 74 L/kg
- Remarks on result:
- other: Conc.in environment / dose:0.01 mg/l
- Key result
- Type:
- BCF
- Value:
- >= 0.51 - <= 4.8 L/kg
- Remarks on result:
- other: Conc.in environment / dose:0.1 mg/l
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979-08-27 to 1979-12-05
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Data from reliable source. Though no detailed test report is available, all tests from the Japanese Authorities are performed according to an OECD guideline and GLP incl. analytics.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)
- Principles of method if other than guideline:
- "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances"
- GLP compliance:
- no
- Specific details on test material used for the study:
- Purity: >= 94 %
- Radiolabelling:
- not specified
- Vehicle:
- yes
- Details on preparation of test solutions, spiked fish food or sediment:
- Chemical name of vehicle: Crystal sugar, HCO-40
PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances) - Chemical name of vehicle: HCO-40, Crystal sugar, - Concentration of vehicle: 1st Concentration area: HCO-40 15 ppm(w/v), Crystal sugar 15 ppm(w/v), 2nd Concentration area: HCO-40 1.5 ppm(w/v), Crystal sugar 1.5 ppm(w/v)
Test organisms - Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Common name: Common carp
- Source: obtained from a commercial fish farm in Japan
- Length at study initiation (lenght definition, mean, range and SD): 10 cm
- Weight at study initiation (mean and range, SD): 30 g
- Lipid content of fish: 2 - 6 %
ACCLIMATION
- Acclimation conditions (same as test or not): flow through at 25 ± 2 °C
- Type and amount of food: obtained from a commercial fish farm in Japan at a rate of 2% of the total body weight
- Feeding frequency: daily, no feeding at the day of sampling - Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 6 wk
- Test temperature:
- 25 ± 2 °C
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: glass tanks, volum = 100 L
- Renewal rate of test solution (frequency/flow rate): 200 - 800 ml/min
- No. of vessels per concentration (replicates): 15 - 20
- No. of vessels per control / vehicle control (replicates): 15 - 20
TEST MEDIUM / WATER PARAMETERS
- Holding medium different from test medium: no
- Intervals of water quality measurement: twice a week - Nominal and measured concentrations:
- 0.01 mg/l and 0.1 mg/l
- Key result
- Type:
- BCF
- Value:
- <= 3.6 L/kg
- Remarks on result:
- other: Conc.in environment / dose:0.06 mg/l
- Key result
- Type:
- BCF
- Value:
- >= 0.33 - <= 11 L/kg
- Remarks on result:
- other: Conc.in environment / dose:0.6 mg/l
Referenceopen allclose all
Table 1. Test results
|
|
|
|
|
|
1stConcentration area |
Test substance concentration (ppb (w/v))) |
98.4 |
96.1 |
97.1 |
96.7 |
|
Bioconcentration factor (L/kg) |
3.1 / 1.3 |
1.6 / 0.92 |
0.51 / 1.7 |
4.8 / 1.8 |
2ndConcentration area |
Test substance concentration (ppb (w/v))) |
8.95 |
8.41 |
8.57 |
8.67 |
|
Bioconcentration factor (L/kg) |
4.8 / 74 |
2.1 / 4.4 |
2.1 / 2.1 |
4.6 / 2.1 |
Table 1. Test results
|
|
|
|
|
|
1stConcentration area |
Test substance concentration (ppb (w/v))) |
98.4 |
96.1 |
97.1 |
96.7 |
|
Bioconcentration factor (L/kg) |
3.1 / 1.3 |
1.6 / 0.92 |
0.51 / 1.7 |
4.8 / 1.8 |
2ndConcentration area |
Test substance concentration (ppb (w/v))) |
8.95 |
8.41 |
8.57 |
8.67 |
|
Bioconcentration factor (L/kg) |
4.8 / 74 |
2.1 / 4.4 |
2.1 / 2.1 |
4.6 / 2.1 |
Description of key information
The substance has low bioaccumulative potential with a BCF ≤ 74 L/kg.
Key value for chemical safety assessment
Additional information
All substances in the category are inert, insoluble in water and octanol, and unreactive. They do not interact with proteins, have a high molecular weight and are insoluble. Thus, they will not be able to penetrate biological membranes. Therefore, the bioaccumulative potential of these substances is expected to be low. The available experimental data can be used for read-across to all substances in this category. The low bioaccumulative potential conclusion is supported by the available studies for the following two substances in the category: CAS 147-14-8 and CAS 1328-53-6.
Both studies were performed according to OECD TG 305C with Cyprinus carpio as the test species. Test organisms were exposed to different concentrations of the substances for 6 weeks in a flow-through system. For the substance CAS 147-14-8, the BCF was determined to be ≤ 3.6 L/kg for a concentration of 0.06 mg/L treatment. Whereas a concentration of 0.6 mg/L treatment resulted in BCFs in a range between 0.33 and 11 L/kg (NITE 1979, K2). Similar results were obtained for substance CAS 1328-53-6. The test organisms were exposed to 0.1 mg/L and 0.01 mg/L of the test item. The BCFs were determined to be in a range between 0.51 and 74 L/kg (NITE 1992, K2).
Based on the findings, all substances in this category are expected to have low bioaccumulative potential with a BCF ≤ 74 L/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.