Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 205-775-0 | CAS number: 150-84-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
An experimental study (Buehler test, OECD guideline 406) was perfomed to determine the skin sensitization potential of Citronellyl acetate. The substance was applied undiluted (MNIC) under occlusive dressing 3 times at D0, D7, D14 during the sensitization phase for 6 hours each. The animals were challenged at D28 with 100% Citronellyl acetate and the cuteaneous response was evaluated at 24h and 48h after challenge. The control group was sensitzed with 100% liquid paraffin and challenged with 100% Citronellyl acetate (MNIC). At 24 hours after challenge, only one animal in the treated group showed discrete erythema at the site of Citronellyl acetate challenge (=5% of sensitized animals). At 48 hours after challenge, none of the treated or control animals showed signs of cutaneous reaction to Citronellyl acetate.
In an Open Epicutanous Test, reported in literature from review article with limited documentation on results, guinea pigs received 21 daily applications of 0.1 ml citronellyl acetate to the clipped flank for induction (Klecak 1985). At days 21 and 35 after beginning of the induction, challenge applications with citronellyl acetate were performed at concentrations, stated as minimal irritating concentration and respective 3 fold serial dilutions. Citronellyl acetate was reported to be negative under the chosen testing conditions.
In a human maximization test, reported in literature from secondary source with limited documentation, 25 subjects received five occlusive applications of citronellyl acetate for alternate-day 48 h periods (Kligman, 1971). After a ten days rest period, an occlusive 48 h challenge application was done on a fresh site with a concentration of 4% in petrolatum. The evaluation after patch removal and 24 h thereafter revealed no dermal effects. Therefore citronellyl acetate was not sensitizing under the chosen testing conditions.
Migrated from Short description of key information:
- Buehler Test (OECD 406): not sensitizing (BASF 32H0442/03X044, 2014)
Justification for classification or non-classification
The present data on dermal sensitization are not sufficient to fulfill the criteria laid down in 67/548/EEC and regulation (EU) 1272/2008, and therefore, a non-classification is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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