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EC number: 205-516-1 | CAS number: 141-97-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The test item EAA was tested for skin and irritation on rabbits. In the key study according to OECD Guideline 404 (Acute dermal irritation / corrosion) similar or equivalent to EU Method B.4. The test item was not irritant to the skin of the rabbit and no corrosive effects were noted. In the key study according to OECD Guideline 405 (Acute eye irritation / corrosion) similar or equivalent to EU Method B.5), EAA was found to be non-irritating to rabbit eyes. There is no data available on respiratory irritation. However, there is no indication for respiratory irritation from handling and use.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 1983
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- - Batch-no: 15.07.83
- Storage: at 22°C in the dark - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- number of animals: 3
- Weight at study initiation: 2800-3200 mg/kg
- Housing: single housing - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 ml test item was applied on a 2.5 x 2.5 cm patch
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- Observation 30 minutes, 24 hours, 48 hours and 72 hours after removal of patch
- Number of animals:
- 3 animals
- Details on study design:
- no data
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Neither erythema nor oedema were observed throughout the study.
- Other effects:
- none
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance was classified as non-irritant to rabbit skin
- Executive summary:
The study was performed in 1983 under GLP according to OECD 404. Three albino rabbits were treated semi-occlusive with 0.5 ml test item was applied on a 2.5 x 2.5 cm patch. Observation times were 24, 48 and 72 hours after removal of the patch. Neither erythema nor oedema were observed in this study. Therefore, EAA is not irritating to rabbit skin.
Reference
The results are summarized below:
Observation |
Mean values over 24, 48 & 72 hours |
Mean value |
||
No.1 |
No.2 |
No.3 |
||
Erythema |
0 |
0 |
0 |
0 |
Oedema |
0 |
0 |
0 |
0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- - Batch-no.: 15.07.83
- Storage: at room temperature in the dark - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- number of animals: 3
- Weight at study initiation: 3200-3500 mg/kg
- Housing: single housing - Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- Amount applied: 0.1 ml
- Duration of treatment / exposure:
- Duration of treatment was 24 hours
- Observation period (in vivo):
- Obervations were done at 1, 24, 48 and 72 hours and 7, 14 and 21 days after application
- Number of animals or in vitro replicates:
- 3 animals were used in this study
- Details on study design:
- The treated eyes were rinsed 24 hours after application.
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.22
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.44
- Max. score:
- 2
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- other: scores observed one hour after treatment
- Irritant / corrosive response data:
- The test item showed irritating effects in this test. All effects on conjunctiva (chemosis and redness) and on iris were found to be reversible within 48 or 72 hours after treatment.
- Other effects:
- Slight secretion was noted in the treated eye of one animal one hour after application.
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test item is slightly irritating to the rabbit eye; however classification/labelling according GHS-criteria is not necessary.
- Executive summary:
The study was performed in 1983 under GLP according to OECD 405. Three albino rabbits were treated; 0.1 ml test item was applied into the conjunctival sac of the eye. Observation times were 1, 24, 48 and 72 hours and 7 days after treatment . The test item showed slight irritating effects in this test. The effects on conjunctiva (chemosis and redness) and on iris were found to be reversible within 48 and 72 hours after treatment.
In conclusion, EAA needs not to be classified as eye-irritant.
Reference
See table above.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Key – Skin irritation
A study was performed in 1983 as GLP-study according to OECD 404. Three albino rabbits were treated semi-occlusive with 0.5 ml test item was applied on a 2.5 x 2.5 cm patch. Observation times were 24, 48 and 72 hours after removal of the patch. Neither erythema nor oedema were observed in this study. Therefore, EAA is not irritating to rabbit skin.
Supporting – Skin irritation
Another study was performed in 1974, following the DOT (Transport Classification) Guidelines. 6 rabbits were used in this test. The patches consisted of 1.5 inch x 1.5 inch 12 ply gauze squares. The patches were secured to the area by thin bands of adhesive tape (occlusive application). The material to be tested (0.5 ml, was introduced beneath the patch. The entire trunks of the animals were then wrapped in clear plastic trunk bands. Erythema of score 2 were noted in 5 out of 6 animals 4h hours after removal of the patch. No oedema were observed. These findings were completely reversible within 48 hours. Therefore, EAA is not irritating to rabbit skin
Key - Eye irritation
The study was performed in 1983 according to OECD 405. Three albino rabbits were treated; 0.1 ml test item was applied into the conjunctival sac of the eye. Observation times were 1, 24, 48 and 72 hours and 7 days after treatment . The test item showed slight irritating effects in this test. The effects on conjunctiva (chemosis and redness) and on iris were found to be reversible within 48 and 72 hours after treatment.
In conclusion, EAA needs not to be classified as eye-irritant.
Waiver - Respiratory irritation
There is no data available on respiratory irritation.
Justification for selection of skin
irritation / corrosion endpoint:
Guideline study; Klimisch 1
Justification for selection of eye irritation endpoint:
Guideline study; Klimisch 1
Justification for classification or non-classification
Based on the data available the substance is not classified or labeled according to Directive 67/548/EEC (DSD) or Regulation 1272/2008/EC (CLP).
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