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EC number: 204-129-5 | CAS number: 116-16-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Hexachloroacetone doesn`t require labelling for either skin or eye irritation:
According to the EC-Commission directive 67 /548/EEC and its subsequent amendments on the approximation of the laws, regulations and administrative provision relating to the classification, packaging and labelling of dangerous substances and the results obtained under the present test
conditionsHexachloraceton wasnon irritating to skin, hence, no labelling is required.
According to the EC-Commission directive 67 /548/EEC and its subsequent amendments on the approximation of the Laws, regulations and administrative provision relating to the classification, packaging and labelling of dangerous substances and the results obtained under the present test
conditions Hexachloraceton was non irritating to eyes, hence, no labelling is required.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline Study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: LPT Laboratory of Pharmacology and Toxicology KG; branch Löhndorf; D-24601 Löhndorf/Post Wankendorf
- Age at study initiation: approx. 11 months
- Weight at study initiation: 2.3-2.7 kg
- Housing: Before and after the 4-hour exposure period, the animals were kept singly in cages measuring 425 mm x 600 mm x 380 mm.
During the exposure period, the animals were kept singly in restrainers which allowed free movement of the head but prevented a complete body turn. The cages excluded irritation of the skin by excrements and urine.
- Diet: ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C ± 3°C
- Humidity (%): 55% ± 15%
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL (approx. 6 cm²) - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: dorsal area of the trunk
- coverage: approx. 6 cm²
- Type of wrap if used: patch
REMOVAL OF TEST SUBSTANCE
- no residual test substance had to be removed - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 9 days
- Score:
- 0
- Irritation parameter:
- other: eschar/oedema formations
- Basis:
- mean
- Time point:
- other: 9 days
- Score:
- 0
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to the EC-Commission directive 67 /548/EEC and its subsequent amendments on the approximation of the laws, regulations and
administrative provision relating to the classification, packaging and labelling of dangerous substances and the results obtained under the present
test conditionsHexachloraceton wasnon irritating to skin, hence, no labelling is required. - Executive summary:
Test system: acute skin irritation test (patch test) in rabbits according to EC guideline 8.4. and OECD guideline 404
Test substance: Hexachloraceton. Under the present test conditions three rabbits were exposed for 4 hours to 0.5 mL Hexachloraceton/ patch and animal (semi-occlusive condition). An erythema (grade 1) was noted in animal no. 1 from 24 hours up to 7 days and in animal nos. 2 and 3 from 24 hours up to 8 days after patch removal. An oedema (grade 1) was noted in animal no. one at 60 min, in animal no. two from 60 min up to 24 hours, and in animal no. three from 60 min up to 48 hours after patch removal.
There were no systemic intolerance reactions.
According to the EC-Commission directive 67 /548/EEC and its subsequent amendments on the approximation of the laws, regulations and administrative provision relating to the classification, packaging and labelling of dangerous substances and the results obtained under the present test conditionsHexachloraceton wasnon irritating to skin, hence, no labelling is required.
Reference
Under the present test conditions three rabbits were exposed for 4 hours to 0.5 ml Hexachloraceton/ patch and animal (semi-occlusive condition). An erythema (grade1) was noted in animal no. 1 from 24 hours up to 7 days and in animal nos. 2 and 3 from 24 hours up to 8 days after patch removal. An oedema (grade 1) was noted in animal no. one at 60 min, in animal no. two from 60 min up to 24 hours, and in animal no. three from 60 min up to 48 hours after patch removal. There were no systemic intolerance reactions.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline Study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source/Breeder: LPT Laboratory of Pharmacology and Toxicology KG; branch Löhndorf; D-24601Löhndorf/Post Wankendorf
- Age at study initiation: approx. 10 months
- Weight at study initiation: 2.6-2.9 kg
- Housing: For 8 hours following test substance application, the animals were kept singly in restrainers which allowed free movement of the head but prevented a complete body turn, wiping of the eyes with the paws and excluded irritation of the eye by excrements and urine.
During the acclimatisation period and after the 8-hour period in restrainers, the animals were kept singly in cages with dimensions of 425 mm x 600 mm x 380 mm
- Diet: ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C ± 3°C
- Humidity (%): 55% ± 15%
- Photoperiod (hrs dark / hrs light): 12/12, 150 lux - Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL per eye in 3 animals - Duration of treatment / exposure:
- 1 test day
- Observation period (in vivo):
- 72 h
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE: no washing done
TOOL USED TO ASSESS SCORE: fluorescein - Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to the EC-Commission directive 67 /548/EEC and its subsequent amendments on the approximation of the Jaws, regulations and administrative provision relating to the classification, packaging and labelling of dangerous substances and the results obtained under the present test conditionsHexachloraceton wasnon irritating to eyes, hence, no labelling is required.
- Executive summary:
Test system: acute eye irritation study by instillation into the conjunctival sac of rabbits according to EC guideline B.5. and OECD guideline 405. Test substance: Hexachloraceton
Under the present test conditions a single instillation of 0.1 ml Hexachloraceton per animal into the conjunctival sac of the right eye of three rabbits caused the following effects:
Corneal opacity(grade 1) was observed in animal no. 3 at 24 hours after instillation.
The fluorescein test performed after 24 hours revealed corneal staining in animal no. 3 (1/4 of the surface).
Conjunctival redness(grade 1) was noted in all animals from 1 hour up to 24 hours, in animal no. 3 up to 48 hours after instillation.
Conjunctival chemosis(grade 2) was observed in animal nos. one and two at 1 hour after instillation.Conjunctival chemosis(grade 1) was observed in animal no. two 24 hours after instillation, in animal no. three in 1 hour to 48 hours after instillation.
Theiriswas not affected by instillation of the test compound.
There were no systemic intolerance reactions.
According to the EC-Commission directive 67 /548/EEC and its subsequent amendments on the approximation of the Jaws, regulations and administrative provision relating to the classification, packaging and labelling of dangerous substances and the results obtained under the present test conditionsHexachloraceton wasnon irritating to eyes, hence, no labelling is required.
Reference
Under the present test conditions a single instillation of 0.1 mL Hexachloraceton per animal into the conjunctival sac of the right eye of three rabbits caused the following effects:
Corneal opacity (grade 1) was observed in animal no. 3 at 24 hours after instillation.
The fluorescein test performed after 24 hours revealed corneal staining in animal no. 3 (1 /4 of the surface).
Conjunctival redness (grade 1) was noted in all animals from 1 hour up to 24 hours, in animal no. 3 up to 48 hours after instillation.
Conjunctival chemosis (grade 2) was observed in animal nos. one and two at 1 hour after instillation. Conjunctival chemosis (grade 1) was observed in animal no. two 24 hours after instillation, in animal no. three in 1 hour to 48 hours after instillation.
The iris was not affected by instillation of the test compound.
There were no systemic intolerance reactions.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Test system: acute skin irritation test (patch test) in rabbits according to EC guideline 8.4. and OECD guideline 404
Test substance: Hexachloraceton.Under the present test conditions three rabbits were exposed for 4 hours to 0.5 mL Hexachloraceton/ patch and animal (semi-occlusive condition). An erythema (grade 1) was noted in animal no. 1 from 24 hours up to 7 days and in animal nos. 2 and 3 from 24 hours up to 8 days after patch removal.An oedema (grade 1) was noted in animal no. one at 60 min, in animal no. two from 60 min up to 24 hours, and in animal no. three from 60 min up to 48 hours after patch removal.
There were no systemic intolerance reactions.
Test system: acute eye irritation study by instillation into the conjunctival sac of rabbits according to EC guideline B.5. and OECD guideline 405.Test substance: Hexachloraceton
Under the present test conditions a single instillation of 0.1 ml Hexachloraceton per animal into the conjunctival sac of the right eye of three rabbits caused the following effects: Corneal opacity (grade 1) was observed in animal no. 3 at 24 hours after instillation.
The fluorescein test performed after 24 hours revealed corneal staining in animal no. 3 (1/4 of the surface).
Conjunctival redness(grade 1) was noted in all animals from 1 hour up to 24 hours, in animal no. 3 up to 48 hours after instillation.
Conjunctival chemosis(grade 2) was observed in animal nos. one and two at 1 hour after instillation.Conjunctival chemosis(grade 1) was observed in animal no. two 24 hours after instillation, in animal no. three in 1 hour to 48 hours after instillation.
Theiriswas not affected by instillation of the test compound.
There were no systemic intolerance reactions.
Justification for selection of skin irritation / corrosion endpoint:
OECD 404 guideline study
Justification for selection of eye irritation endpoint:
OECD 405 guideline study
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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