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Diss Factsheets
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EC number: 202-257-6 | CAS number: 93-55-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Rat LD50 oral: 4490 mg/kg
Dermal LD50 rabbit: 4490 mg/kg
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Principles of method if other than guideline:
- The experimental method followed the procedure described in earler paper (Smyth et al. 1962).
- GLP compliance:
- no
- Remarks:
- pre GLP
- Species:
- rat
- Route of administration:
- oral: unspecified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 4 490 other: mg/kg
- Based on:
- not specified
- Remarks on result:
- other: 2330 - 8640 mg/kg
- Interpretation of results:
- not classified
- Remarks:
- according to the CLP Regulation (EC 1272/2008)
- Conclusions:
- LD50 rat: 4490 mg/kg
- Executive summary:
The experimental method followed the procedure described in earler paper (Smyth et al. 1962). No further details are available.
Single oral LD50 for rats has been reported to be 4490 (2330 -8640) mg/kg.
Conclusion
LD50 rat: 4490 mg/kg
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 4 490 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Principles of method if other than guideline:
- The experimental method followed the procedure described in earler paper (Smyth et al. 1962).
- GLP compliance:
- no
- Remarks:
- pre GLP
- Species:
- rabbit
- Type of coverage:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 4 490 other: mg/kg
- Based on:
- not specified
- Remarks on result:
- other: 2110-9540 mg/kg
- Interpretation of results:
- not classified
- Remarks:
- according to the CLP Regulation (EC 1272/2008)
- Conclusions:
- LD50 rabbit: 4490 mg/kg
- Executive summary:
The experimental method followed the procedure described in earler paper (Smyth et al. 1962). No further details are available. Single oral LD50 for rats has been reported to be 4490 (2110 -9540) mg/kg.
Conclusion
LD50 rabbit: 4490 mg/kg
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 4 490 mg/kg bw
Additional information
The acute toxicity potential of propiophenone has been investigated taking also into consideration data on the structural analogue acetophenone: the Read Across approach can be considered appropriate for the assessement of acute toxicity. Details can be found in the Read Across justification document attached in section 13 of IUCLID.
ORAL ROUTE
An experiment has been performed administrating an oral single dose of propiophenone to rats. The LD50 value has been reported to be 4490 (2330 -8640) mg/kg (Carpenter et al, 1974). Because the available information is reported by literature secondary source and many details, which are foundamental in order to assign a reliability to the study, are lacking, the available data on structural analogous have been taken into account.
It has to be noted that the preparatory work for toxicological evaluations of food additives and contaminants by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) on propriophenone has been conducted. The data on uses and intake requested by the Committee at its fiftythird meeting were provided and raised no safety concern for propiophenone (WHO, 2002).
INHALATION ROUTE
Data on the structural analogue acetophenone are reported in literature monograph. Rowe & Wolf (1963) reported no deaths in rats exposed for 8 hr to an atmosphere saturated with acetophenone [Flash point, 82 °C; vapor pressure (% in saturated air), 0-45 %; evaporation rate (ether = 1), 0-06.] (Opdyke, 1973).
DERMAL ROUTE
An experiment has been performed administrating a dermal single dose of propiophenone to rabbits. The LD50 value has been reported to be 4490 (2110 -9540) mg/kg (Carpenter et al, 1974). Because the available information is reported by literature secondary source and many details, which are foundamental in order to assign a reliability to the study, are lacking available data on structural analogous have been taken into account.
REFERENCE
Opdyke (1973). Monographs on fragrance raw materials: Acetophenone. Food and Cosmetics Toxicology, 11: 99-100
Rowe, V. K. & Wolf, M. A. (1963). Ketones. In Industrial Hygiene and Toxicology. 2nd ed. Edited by F. A. Patty, Vol. II, p. 1763. Interscience Publishers, New York.
World Health Organization (WHO) (2002). Joint FAO/WHO Expert Committee on Food Additives (2001, Rome, Italy) Evaluation of certain food additives and contaminants: fifty-seventh report of the Joint FAO/WHO Expert Committee on Food Additives. (WHO technical report series ; 909) ttp://apps.who.int/iris/bitstream/10665/42578/1/WHO_TRS_909.pdf
Justification for classification or non-classification
According to the CLP Regulation (EC 1272/2008), 3.1 Acute toxicity section, substances can be allocated to one of four toxicity categories based on acute toxicity by the oral, dermal or inhalation route according to the numeric criteria. Acute toxicity values are expressed as (approximate) LD50 (oral, dermal) or LC50 (inhalation) values or as acute toxicity estimates (ATE).
The oral LD50 value was established to be greater than 2000 mg/kg (i.e. 4490 mg/kg), therefore the test substance is out of any classification limit for acute oral toxicity (oral acute toxicity category 4: 300 < ATE ≤ 2000 mg/kg bw).
The dermal LD50 value was established to be higher than 2000 mg/kg (i.e. 4490 mg/kg), which exceeded the highest CLP limit for classification (dermal acute toxicity category 4: 1000 < ATE ≤ 2000 mg/kg bw).
In conclusion, the test substance is non classified for oral/dermal acute toxicity, according to the CLP Regulation (EC 1272/2008).
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