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EC number: 202-257-6 | CAS number: 93-55-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Quantitative Structure - Biodegradability relationships for alcohols, ketones and alicyclic compounds.
- Author:
- Vaishnav D.D., Boethling R.S. and Babeu L.
- Year:
- 1 987
- Bibliographic source:
- Chemosphere, Vol.16, No.4, pp 695-703, 1987
Materials and methods
- Principles of method if other than guideline:
- The 5-day BOD value ahs been determined using acclimated inocula of wastewater origin and using the techique according to APHA 1980 (American Public Health Association (1980) Standard methods for the examination of water and wastewater, 15th ed. American Public Health Association, Washington, D.C., p. 70).
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-phenylethanone
- IUPAC Name:
- 1-phenylethanone
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, domestic, adapted
- Details on inoculum:
- - Inoculum: acclimated microbial cultures capable of degrading alcohols and ketones as sole carbon and energy sources were obtained by a conventional enrichment technique.
- Source of inoculum: domestic sewage.
- Incubation: mineral salts medium (prepared according to the OECD,1981) containing chemical and sewage was incubated on a rotary shaker (120 rpm) at 21 ± 3 °C.
- Storage: cultures were stored individually at 4 °C in 0.2 M phosphate buffer (pH 6.8), containing 100 µl/l of the enrichment substrate.
- Initial cell/biomass: 1 ml of acclimated seed. - Duration of test (contact time):
- 5 d
Initial test substance concentration
- Initial conc.:
- 250 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Test temperature: 21 ± 3 °C
TEST SYSTEM
- Culturing apparatus: 300-ml BOD bottles, filled with 20 ml of dilution water. The bottles were then filled to capacity with dilution water, sealed, and incubated.
- Number of culture flasks: 8 replicates.
- Measuring equipment: YSI 54 oxygen meter with a self stirring probe.
SAMPLING
- Sampling frequency: Sampling was performed on the first day (t = 0 days) and on the 5th day (t = 5 days) for the measurement of dissolved oxygen
- DO concentration
EVALUATION
Biodegradation of the alcohols and ketones was determined using the BOD technique (American Public Health Association (1980) Standard methods for the examination of water and wastewater, 15th ed. American Public Health Association, Washington, D.C., p. 70).
The DO concentrations in randomly selected bottles were determined by the azide modification of the iodometric titration method. BOD values showing unadjusted DO depletions of at least 2 mg/l and residual DO of at least 1 mg/l were corrected for the seed BOD, and used to calculate a mean BOD for the chemical.
TEST ITEM CONCENTRATIONS
Initial concentrations of test chemical in the BOD bottles ranged from 0 to 3.2 µl/l, and never exceeded the water solubility of the chemical.
Results and discussion
% Degradation
- Remarks on result:
- not measured/tested
BOD5 / COD results
BOD5 / COD
- Remarks on result:
- other: details below
Any other information on results incl. tables
The mean 5-day BOD resulted 5.61 (SD: 0.17) mmol BOD/ mmol test chemical. The percentage of ThOD was estimated to be 59.1 and the log P 1.58.
The most probable degradation pathway for ketons involves insertion of an oxygen atom next to the keto group by a ketone monooxygenase, producing an ester that is subsequently hydrolyzed, presumably to products that are easily degraded. The log (% removal) appears to be linearly correlated with log P.
Applicant's summary and conclusion
- Conclusions:
- The mean 5-day BOD resulted 5.61 (SD: 0.17) mmol BOD/ mmol test chemical.
- Executive summary:
The 5-day BOD value ahs been determined using acclimated inocula of wastewater origin and using the techique according to APHA 1980 (American Public Health Association (1980) Standard methods for the examination of water and wastewater, 15th ed. American Public Health Association, Washington, D.C., p. 70).
The mean 5-day BOD resulted 5.61 (SD: 0.17) mmol BOD/ mmol test chemical. The percentage of ThOD was estimated to be 59.1 and the log P 1.58.
The most probable degradation pathway for ketons involves insertion of an oxygen atom next to the keto group by a ketone monooxygenase, producing an ester that is subsequently hydrolyzed, presumably to products that are easily degraded. The log (% removal) appears to be linearly correlated with log P.
Conclusion
The mean 5-day BOD resulted 5.61 (SD: 0.17) mmol BOD/ mmol test chemical.
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