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EC number: 240-383-3 | CAS number: 16291-96-6 An amorphous form of carbon produced by partially burning or oxidizing wood or other organic matter.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Remarks:
- other: in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: del estudio se realizó de acuerdo a ICCVAM protocolo recomendado por el método HET-CAM (noviembre de 2006)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: According to ICCVAM recommended HET-CAM Method Protocol (Nov. 2006)
- Deviations:
- no
- Principles of method if other than guideline:
- El método de HET-CAM es una alternativa en el procedimiento in vitro que permite predecir el potencial irritativo o corrosivo ocular de una sustancia mediante la observación del desarrollo de los efectos de irritación en la membrana del huevo de pollo corioalantoidea (CAM).
La CAM es una parte vital de la membrana vascular fetal, con un sistema cerrado de los vasos sanguíneos. Dada la alta vascularización de esta membrana, este método se propone proporcionar información sobre los efectos que pueden ocurrir en la conjuntiva (una estructura ocular altamente vascularizada) tras la exposición a una sustancia de ensayo. - GLP compliance:
- no
Test material
- Reference substance name:
- Charcoal
- EC Number:
- 240-383-3
- EC Name:
- Charcoal
- Cas Number:
- 16291-96-6
- Molecular formula:
- C
- IUPAC Name:
- Carbón vegetal
- Details on test material:
- Name: Charcoal (Probe 1: C-Fix = 73.3%)
Batch No.: 19062009 1PP
Appearance: Charcoal typic
CAS No.: 16291-96-6
EINECS No.: 240-383-3
Purity: C-Fix: 73.3%
Date of expiry: December 2030
Storage conditions: Room temperature 20 ± 5 °C, keep away from humidity
Constituent 1
Test animals / tissue source
- Species:
- other: test in vitro, sin animales
- Strain:
- other: no aplica
- Details on test animals or tissues and environmental conditions:
- no aplica al ser ensayo in vitro
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 50 mg aprox.
- Duration of treatment / exposure:
- 300 sec
- Observation period (in vivo):
- 300 sec
- Number of animals or in vitro replicates:
- no aplica al ser test in vitro
- Details on study design:
- Test system:
The HET-CAM was carried out with Lohmann Selected Leghorn chicken's eggs. The eggs were obtained 9 days before the start of the test. Eggs were incubated at 38.5 °C, 58.8% humidity for nine days, periodically rotated. On day eight the eggs were candled and non-viable eggs were discarded. The rest of the eggs were placed upwards in the incubator for another day.
Test groups:
Negative control: 0.9% NaCl, on 3 eggs; 300 μL each
Positive control: 1% SDS solution in deionized water, on 3 eggs; 300 μL each
Positive control: 0.1 N NaOH, on 3 eggs; 300 μL each
Test item: Neat charcoal about 50 mg of <100 µm size
Experimental performance:
After application of test item, negative and positive control, the eggs were observed for a period of 300 sec. Three endpoints were observed. The time when that particular endpoint was observed was noted. The three endpoints were:
• hemorrhage
• blood vessel lysis
• coagulation
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- other: Provided on the above section 'any information on materials and methods incl. tables
- Time point:
- other: 300 sec
- Score:
- ca. 0
- Max. score:
- 21
- Reversibility:
- not specified
- Remarks on result:
- other: resultado de no irritante
- Irritant / corrosive response data:
- The irritation score (IS) for charcoal (IS:0.0) was not different from the negative control (IS: 0). The positive controls (0.1N NaOH, and 1% SDS) caused values (IS: 19.99 and 11.25, respectively) that fell within the classification of severely irritating to the eye.
- Other effects:
- no aplica
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- el carbón vegetal no exhibe poder irritante ocular
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