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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 258-981-8 | CAS number: 54112-23-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
In accordance with Column 2 of REACH, Annexes VIII, if the substance is highly insoluble in water (water solubility: 8.22 µg/L) and considering exposure to the environment is negligible, the short-term studies to aquatics, sediment, soil and microorganisms do not need to be conducted.
Instead besides a freshwater algae toxicity test (OECD 201) was performed, seconded by a long-term toxicity to Daphnia study (reproduction test according to OECD 211) and a fish early life stage study (OECD 210) have been performed.
The long-term daphnia study and the fish early life-stage study were supported by a solubility study for the substance in the respective test media used for these studies (Elendt M4 medium and ISO water) to determine the true maximum solubility of the test substance in these test media, as during performance of the studies precipitation was observed, affecting the study findings.
The growth inhibitions study with algae resulted in no effects on algae growth up to the highest concentration tested (320 µg/L nominal, 127 µg/L actual, determined as sum of dissolved and particulate substance).
The daphnia reproduction study (semi-static) showed effects on reproduction and the NOEC found in this study was 12.8 µg/L nominal / 10.1 µg/L measured as time weighted average. As the determination of true water solubility in Elendt M4 medium used in this study was found being less than 0.512 µg/L, the NOEC was more than a magnitude above the limit of solubility and effects seen were attributable to physical properties of undissolved particulates.
Also, in the fish early life-stage test (flow-through) effects were noticed at high concentrations and the NOEC in this study was set to 2.56 µg/L nominal / 2.25 µg/L measured as arithmetic mean. However, the determination of true water solubility in ISO water, used in this study, was found being at maximum 0.0322 µg/L, and thus, the NOEC was more than two orders of magnitude above the limit of solubility in the test medium and effects seen also in this case were attributable to physical properties of undissolved particulates.
In conclusion, the test substance had no toxic effects on green algae, daphnia and zebrafish in long-term studies performed, when tested at its maximum solubility in test media.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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