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Diss Factsheets
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EC number: 684-597-9 | CAS number: 1072005-10-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- fixed concentration procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Decanoic acid, mixed diesters with octanoic acid and propylene glycol
- EC Number:
- 271-516-3
- EC Name:
- Decanoic acid, mixed diesters with octanoic acid and propylene glycol
- Cas Number:
- 68583-51-7
- Molecular formula:
- C21H44O6
- IUPAC Name:
- Decanoic acid, mixed diesters with octanoic acid and propylene glycol
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: not specified
- Age at study initiation: young
- Weight at study initiation: 285 - 465 g
Administration / exposure
- Route of administration:
- inhalation: mist
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- Each group of guinea pigs was placed in a 75 liter chamber equipped with an air supply of 10 liters per minute. After the test animals became accustomed to the chamber conditions, the test item was sprayed into the air supply at a rate calculated to yield the required concentration of 200 ppm. Particle counts were performed every 30 minutes using Bausch and Lomb particle counter (model 40-1A). The chamber temperature was recorded every 30 minutes. The control group was exposed to only air for the same length of time.
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 6 h
- Concentrations:
- 200 ppm (equivalent to 5952 mg/m³)
- No. of animals per sex per dose:
- 200 ppm: 6 male, 6 female
control: 3 animals - Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 200 ppm
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Remarks on result:
- other: equivalent to 5952 mg/m³
- Sex:
- male/female
- Dose descriptor:
- discriminating conc.
- Effect level:
- 200 ppm
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Remarks on result:
- other: equivalent to 5952 mg/m³
- Mortality:
- No animals died or were sacrificed in moribund condition.
- Clinical signs:
- other: No abnormal observations were made on the animals immediately after exposure or during the 7 day observation period.
- Gross pathology:
- In the necropsies and microscopic examination no changes in the animals were detected, which could be related to the treatment.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute inhalation study on guinea pigs over 6h the LC50 was above 200 ppm (equivalent to 5952 mg/m³):
- Executive summary:
An acute inhalation study on guinea pigs over 6h with the test item was performed. The concentration of 200 ppm was prayed into the air supply for 12 guinea pigs (6 male, 6 female). After the exposure of 6h, the animals were observed daily for a period of 7 days and their appearance and behavior was noted. At the completion of the observation period a gross necropsy was performed, all major tissues and organs were preserved and the lungs and all grossly abnormal organs were examined microscopically. The 6 hour inhalation produced no pathologic changes in the animals which could be related to treatment. No abnormal observations were made on the animals immediately after exposure or during the 7 day observation period. No animals died or were sacrificed in moribund condition. Therefore the discriminating dose is 200 ppm, the LC50 > 200ppm (equivalent to 5952 mg/m³).
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