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EC number: 275-269-2 | CAS number: 71215-81-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991: May 14 to October 8
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Version / remarks:
- (1984)
- GLP compliance:
- no
- Analytical monitoring:
- not specified
- Test organisms (species):
- activated sludge, domestic
- Details on inoculum:
- The tests were run with aerobic activated sludge from a domestlc waste-water treatment plant (ARA, Sissach/Switzerland).
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Post exposure observation period:
- 10 minutes
- Hardness:
- not specified
- Test temperature:
- 21.5°C
- pH:
- initial pH: 8.2
- Dissolved oxygen:
- not specified
- Salinity:
- not specified
- Conductivity:
- not specified
- Nominal and measured concentrations:
- The following flasks were filled up to 500 mL final volume according to:
Flask 1 (control): 0 mg/L
Flask 12 (control): 0 mg/L
Flask 5 (ACDMA): 100 mg/L
Flask 6 (ACDMA): 10 mg/L
Flask 2 (3,5-dichlorophenol sodium salt): 50 mg/L
Flask 3 (3,5-dichlorophenol sodium salt): 10 mg/L
Flask 4 (3,5-dichlorophenol sodium salt): 3.2 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass-flask (>500 mL)
- Aeration: glass-flasks aerated with 0.5 L/minute of an air-flow of about 0.2 L/minute instead of 0.5L/minute to prevent possible foam development.
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 2
- No. of vessels per vehicle control (replicates): 0
- No. of vessels per abiotic control (replicates): 0
OTHER TEST CONDITIONS
- Adjustment of pH: not specified (initial pH of 8.2)
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : oxygen consumption rate (per minute)
TEST CONCENTRATIONS
- Test concentrations: 10 and 100 mg/L - Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol
- Duration:
- 3 h
- Dose descriptor:
- IC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Results with reference substance (positive control):
- IC50 of 3,5-dichlorophenol has been measured as 9.0 mg/L
- Validity criteria fulfilled:
- yes
- Remarks:
- IC50 of positive control is in the range of 5-30 mg/L. The variation between the two control samples (start, end) is not >15%.
- Conclusions:
- Influence of ACDMA on oxygen consumption of activated sludge has been determined in test performed according to OECD TG 209 to derive an IC50 >100 mg/L.
- Executive summary:
Influence of ACDMA on oxygen consumption of activated sludge has been determined in test performed according to OECD TG 209 to derive an IC50 >100 mg/L.
Reference
Influence of ACDMA on oxygen consumption of activated sludge
Flask N° |
Chemical |
Concentration of test chemical (mg/L) |
Oxygen consumption (mg O2/L min.) |
Inhibition (%) |
Starting pH |
|
1 |
Control |
- |
0.69 |
Mean: 0.73 Deviation: 11.6% |
- |
8.2 |
12 |
Control |
- |
0.77 |
- |
8.2 |
|
5 |
ACDMA |
100 |
0.59 |
19.2 |
8.2 |
|
6 |
ACDMA |
10 |
0.60 |
17.8 |
8.2 |
Influence of 3,5-dichlorophenol sodium salt on oxygen consumption of activated sludge
Flask N° |
Chemical |
Concentration of test chemical (mg/L) |
Oxygen consumption (mg O2/L min.) |
Inhibition (%) |
Starting pH |
|
1 |
Control |
- |
0.69 |
Mean: 0.73 Deviation: 11.6% |
- |
8.2 |
12 |
Control |
- |
0.77 |
- |
8.2 |
|
2 |
3,5-dichlorophenol |
50 |
0.06 |
91.8* |
8.2 |
|
3 |
3,5-dichlorophenol |
10 |
0.32 |
56.2* |
8.2 |
|
4 |
3,5-dichlorophenol |
3.2 |
0.57 |
21.9* |
8.2 |
*: values used for the calculation of linear regression.Y = 58.048 x log(dose)-5.364 (R=0.996) -> IC50 : 9.0 mg/L
Description of key information
Influence of ACDMA on oxygen consumption of activated sludge has been determined in test performed according to OECD TG 209 to derive an IC50 >100 mg/L.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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