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EC number: 701-249-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2012/06/06-2012/07/19
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Dermal absorption with tetrapropenyl phenol (“TPP”, EC 310-154-3; AKA phenol, dodecyl-, branched) is provided as it is relevant for the risk assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 428 (Skin Absorption: In Vitro Method)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Phenol, dodecyl-, branched
- EC Number:
- 310-154-3
- EC Name:
- Phenol, dodecyl-, branched
- Cas Number:
- 121158-58-5
- Molecular formula:
- C15H24O to C21H36O
- IUPAC Name:
- Phenol, alkyl branched (species comprising decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl substituents)
- Test material form:
- liquid: viscous
- Details on test material:
- - Name of test material (as cited in study report): CASRN 74499-35-7
- Substance type: Pure active substance
- Physical state: liquid
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- C14 ring label
Test animals
- Species:
- rat
- Strain:
- other: RCCHan:WIST (SPF): Wistar
- Sex:
- male
Administration / exposure
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 6 hours
- Doses:
- 0.01, 0.1, 1 mg/10 cm2
- No. of animals per group:
- 4 (total of 16)
- Control animals:
- yes
Results and discussion
- Signs and symptoms of toxicity:
- no effects
- Dermal irritation:
- no effects
- Absorption in different matrices:
- [14C]-TPP was systemically absorbed to the same moderate extent for all dose levels tested, i.e. 24-34% (29.8% of the low dose, 33.6% of the middle dose, and 24.2% of the high dose)
Percutaneous absorptionopen allclose all
- Key result
- Time point:
- 6 h
- Dose:
- 0.01
- Parameter:
- amount
- Remarks:
- mg/10cm2
- Absorption:
- 29.8 %
- Key result
- Time point:
- 6 h
- Dose:
- 0.1
- Parameter:
- amount
- Remarks:
- mg/10cm2
- Absorption:
- 33.6 %
- Key result
- Time point:
- 6 h
- Dose:
- 1.0
- Parameter:
- amount
- Remarks:
- mg/10cm2
- Absorption:
- 24.2 %
Any other information on results incl. tables
After 6 hours of exposure, 4.4%, 6.9%, and 3.9% of the low, middle, and high dose were dermally absorbed. Most of the remaining applied dose (58-62%) was dislodged from the application site either by being washed off after the exposure period or recovered in the extracts of the covers and O-rings. At 72 hours, systemic absorption increased to 15.7%, 17.3% and 13.4% of the applied low, middle, and high dose, respectively. Consequently the radioactivity recovered at the application site, skin stripping and remaining treated skin after skin stripping, decreased with time indicating that the residues in skin were very slowly absorbed. Most of the radioactivity at the application site was recovered in lower skin levels (tape strips III – VII and remaining treated skin) i.e. 21.7-23.1% at 6 hours, 13.3-17.0% at 24 hours, 14.6-18.2% at 48 hours and 10.7-16.2% at 72 hours. This amount in the lower skin levels of the application site has to be considered as a depot for absorption and therefore the maximum systemic absorption totally accounted for 29.8% of the low dose, 33.6% of the middle dose, and 24.2% of the high dose.
Concentrations in blood and plasma remained low for all doses. When measurable, concentrations in blood and/or plasma stayed relatively constant with time. Concentrations in plasma were higher than concentrations in blood indicating that test item related material is mostly associated with the plasma fraction of the blood.
The systemically absorbed test item was excreted mainly via feces. After 3 days, 10.05% of the low dose, 11.67% of the mid dose and 9.10% of the high dose were excreted with the feces whereas 1.14% of the low dose, 1.00% of the mid dose and 0.81% of the high dose was excreted with the urine. In the cage wash, 0.10%, 0.15% and 0.12% of the applied low, mid and high dose were recovered, respectively. Three days after start of exposure, 4.45% of the low dose, 4.51% of the mid dose and 3.40% of the high dose were still remaining in the animals (i.e. carcass, whole blood, gastrointestinal tract, and non-treated skin).
Applicant's summary and conclusion
- Conclusions:
- [14C]-TPP was systemically absorbed to the same moderate extent for all dose levels tested, i.e. 24-34% (29.8% of the low dose, 33.6% of the middle dose, and 24.2% of the high dose). The calculated penetration rates increased in a proportional fashion with the dose levels.
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