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Diss Factsheets
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EC number: 204-265-5 | CAS number: 118-61-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
For this enpoint, one key study is available for acute oral toxicity. No data are available on acute toxicity via inhalation or dermal application.
The study has been performed in rats. It did not follow a guideline and was pre-GLP.
Each group of 10 rats were fed orally 0.34, 0.67, 1.31, 2.56 or 5.0 g/kg of test substance as a single dose. The animals were observed for 14 days.
As a result, the test substance can be referred to as a category 4 compound with an LD50 of 1320 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Toxic properties after a single oral dose of the test substance were investigated by observation for a period of 14 days.
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 0.34, 0.67, 1.31, 2.56 and 5.0 g/kg
- No. of animals per sex per dose:
- 10 animals per dose group
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 320 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1.01 - <= 1.63
- Mortality:
- 0/10 at dose level 340 mg/kg bw
0/10 at dose level 670 mg/kg bw
5/10 at dose level 1310 mg/kg bw
10/10 at dose level 2560 mg/kg bw
10/10 at dose level 5000 mg/kg bw - Clinical signs:
- other: - 0.34 - 2.56 g/kg: none; - tremors, labored breathing,flaccid at 5 g/kg
- Gross pathology:
- not specified
- Other findings:
- not specified
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The test substance has an LD50 of 1320 mg/kg bw given as a single dose.
- Executive summary:
The study has been performed in order to investigate the toxic propreties of the test substance. Each group of 10 rats were fed orally 0.34, 0.67, 1.31, 2.56 or 5.0 g/kg of test substance as a single dose. The animals were observed for 14 days.
As a result, the test substance can be referred to as a category 4 compound with an LD50 of 1320 mg/kg bw.
Reference
Distribution of mortality
Observation Day | |||||||||||||||
Dose (g/kg) | Deaths/No. of Animals | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 |
0.34 | 0/10 | ||||||||||||||
0.67 | 0/10 | ||||||||||||||
1.31 | 5/10 | 3 | 2 | ||||||||||||
2.56 | 10/10 | 10 | |||||||||||||
5 | 10/10 | 10 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 320 mg/kg bw
- Quality of whole database:
- The key study is acceptable with restrictions (documentation not complete, no guideline followed, not GLP)
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
For this enpoint, one key study is available for acute oral toxicity. No data are available on acute toxicity via inhalation or dermal application.
The study has been performed in rats. It did not follow a guideline and was pre-GLP.
Each group of 10 rats were fed orally 0.34, 0.67, 1.31, 2.56 or 5.0 g/kg of test substance as a single dose.
The animals were observed for 14 days.
As a result, the test substance can be referred to as a category 4 compound with an LD50 of 1320 mg/kg bw.
Justification for classification or non-classification
Acute oral toxicity
The acute oral toxicity study on rats can be used for classification. According to the CLP legislation a substance is considered acute toxic when the acute toxicity estimates (ATE) for the oral route are =< 2000 mg/kg bodyweight. As the LD50 of the test item is 1320 mg/kg bw, the test substance can be referred to as a category 4 compound.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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