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EC number: 270-821-9 | CAS number: 68478-46-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian cell study: DNA damage and/or repair
- Remarks:
- study proposal for Comet Assay
- Type of information:
- experimental study planned
- Justification for type of information:
- For the test item three in vitro tests were performed from 2017 to 2020. The Ames test according to OECD 471 and the micronucleus test according to OECD 487 have a negative outcome for genotoxicity. However, the HPRT test, which was performed 2018 at LPT showed clear positive genotoxic effects in the absence of metabolic activation. According to the REACH regulation Annex VIII an in vivo genotoxicity study has to be performed if at least one in vitro genotoxicity test showes a positive outcome.
Based on these data, we recommend to perform the combined in vivo mammalian erythrocyte micronucleus test according to OECD 474) and the in vivo mammalian alkaline Comet assay according to OECD 489 (in the liver and the stomach) as the most suitable in vivo genotoxicity tests for the test item.
Literature search showed no other available GLP and or no GLP studies for this endpoint nor any historical human data for the substance. As there are no other similar substances available grouping and read across can not be performed. As the substance is an UVCB substance application of QSAR tools/methods is not applicable.
Other in vitro methods are not relevant as all three endpoints (gene mutation, chromosome aberration, and micronucleus test) are already covered and an in vivo test is necessary after one positive in vitro test according to REACH regulation Annex VIII: According to REACH regulation Annex VIII ….”an in vivo method should be performed if there is one or more positive in vitro test in annex VII or VIII”.
Data source
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 489 (In vivo Mammalian Alkaline Comet Assay)
Test material
- Reference substance name:
- Boron, (benzenemethanamine)trifluoro-, (T-4)-, reaction products with Bu glycidyl ether
- EC Number:
- 270-821-9
- EC Name:
- Boron, (benzenemethanamine)trifluoro-, (T-4)-, reaction products with Bu glycidyl ether
- Cas Number:
- 68478-46-6
- Molecular formula:
- C14H23BF3NO2
- IUPAC Name:
- 1-phenylmethanamine; 7-[(benzylamino)methyl]-10-(butoxymethyl)-5,8,11,15-tetraoxaicosan-13-ol; benzyl(3-butoxy-2-hydroxypropyl)amine; benzyl[3-butoxy-2-(3-butoxy-2-hydroxypropoxy)propyl]amine; dibenzyl(3-butoxy-2-hydroxypropyl)amine
- Test material form:
- liquid: viscous
- Details on test material:
- Boron, (benzenemethanamine)trifluoro-, (T-4)-, reaction products with Bu glycidyl ether, Batch: NC18201915
Constituent 1
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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