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Diss Factsheets
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EC number: 278-140-9 | CAS number: 75214-72-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Not mutagenic
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
IN VITRO GENOTOXICITY
As no data on genotoxicity of the test item was available, the following data was obtained for the Source Substance. It is expected that the Target Substance will present a similar profile. Justification for Read Across is given in Section 13 of IUCLID.
The Source Substance was evaluated for its potential to induce mutagenic effects in an in vitro bacterial inverse mutation assay, according to a method similar to the OECD 471 guideline. Salmonella typhimurium strains TA 1535, TA 1537, TA 1538, TA 98, TA 100 were used. The test material showed no toxicity to the TA-100 indicator strain during the preliminary test. Therefore, mutagenicity tests were performed at eight doses in the range of 1.0-10000.0 μg / plate with and without S9 metabolic activation.
The Source Substance showed no genetic activity in any of the tests conducted and was considered non-mutagenic in these test conditions. The high concentrations used counterbalance the shortcomings that could result from the use of a test material with a low purity used suggesting that the use of the experimental results for the evaluation of mutagenicity is acceptable.
Justification for classification or non-classification
Mutagenicity refers to the induction of permanent transmissible changes in the amount or structure of the genetic material of cells or organisms. These changes may involve a single gene or gene segment, a block of genes or chromosomes.
According to the CLP Regulation (EC) No. 1272/2008, for the purpose of the classification for germ cell mutagenicity, substances are allocated in one of two categories in consideration of the fact that they are:
-substances known to induce heritable mutations or to be regarded as if they induce heritable mutations in the germ cells of humans or substances known to induce heritable mutations in the germ cells of humans (Category 1) or
-substances, which cause concern for humans owing to the possibility that they may induce heritable mutations in the germ cells of humans (Category 2).
Based on results of in vitro gene mutation study performed, it is concluded that the test item did not induce gene mutations in reverse mutation in Salmonella typhimurium strains tested in the absence or presence of S9 metabolism.
According to the REACH Regulation (EC) No. 1907/2006, Annex VII, Column 2, further mutagenicity studies are not necessary to be considered in case of a negative result. Therefore, it is possible to conclude that the test substance is not considered to be genotoxic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.