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EC number: 233-143-4 | CAS number: 10043-84-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from peer reviewed journal
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity study of test material.
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- ChemIDplusA TOXNET Database, 2017
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of test material was performed in mouse.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Manganese sulphate
- EC Number:
- 232-089-9
- EC Name:
- Manganese sulphate
- Cas Number:
- 7785-87-7
- Molecular formula:
- H2O4S.Mn
- IUPAC Name:
- manganese sulphate anhydrous
- Details on test material:
- - Name of test material (as cited in study report):manganese sulphate anhydrous
- Molecular formula :H2O4S.Mn
- Molecular weight :151.0g/mole
- Substance type:Inorganic
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Details on test animal
TEST ANIMALS
- Source: No data available
- Age at study initiation: No data available
- Weight at study initiation:20-22g
- Fasting period before study: No data available
- Housing: polycarbonate cages
- Diet (e.g. ad libitum): The animals were fed Gold Mohur Hind Lever diet ad libitum.
- Water (e.g. ad libitum): water ad libitum.
- Acclimation period:
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 24± 0.5°C
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): a 12 h dark and 12 h
light cycle.
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: de-ionized triple glass distilled water
- Details on oral exposure:
- The test material were dissolved in de-ionized triple glass distilled water
- Doses:
- 2330mg/kg bw
- No. of animals per sex per dose:
- Total :10
0 mg/kg bw: 5
2330mg/kg bw:5 - Control animals:
- yes
- Details on study design:
- The gross behavioural changes were recorded at 30, 60, 120 and 240 min using method of Irwin (1959).10 The changes in rectal temperature were recorded by using the thermocouple probes on Digital precision thermometer-DU-3S (ELLAB, DENMARK).
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 330 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed in treated mouse at 2330mg/kg bw.
- Mortality:
- 50% mortality was observed in treated mouse at 2330mg/kg bw.
- Clinical signs:
- other: Behavioral changes like somnolence (general depressed activity), convulsions or effect on seizure threshold were observed
- Gross pathology:
- no data available
- Other findings:
- no data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- LD50 was considered to be 2330mg/kg bw. When mouse were treated with test material orally.
- Executive summary:
In acute oral toxicity study, maleSwiss strain Albino mice were treated withtest material in dose concentration 2330mg/kg bw orally.The test material were dissolved inde-ionized triple glass distilled water. Each group consisted of 5 animals.50% mortality was observed in treated mouse at 2330 mg/kg bw.Behavioral changes like somnolence (general depressed activity) and convulsions or effect on seizure threshold were observed in treated mice.Therefore, LD50 was considered to be 2330mg/kg bw. When mouse were treated with test material orally.
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