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EC number: 239-741-1 | CAS number: 15667-10-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No acute toxicity test with cyclohexylidenebis[tert-amyl] peroxide is available for invertebrates. The acute toxicity to daphnia is thus read-across from data obtained with cyclohexylidenebis[tert-butyl] peroxide.
Under test conditions, no toxic effect has been observed at the maximum achievable solubility to daphnia.
Key value for chemical safety assessment
Additional information
No acute toxicity test with cyclohexylidenebis[tert-amyl] peroxide is available for invertebrates. The acute toxicity to invertebrates is thus read-across from data obtained with cyclohexylidenebis[tert-butyl] peroxide.
The acute toxicity of cyclohexylidenebis[tert-butyl] peroxide was evaluted in the Cladoceran Daphnia magna Straus (clone 5) using a 48 -hour static test according to OECD guideline No. 202 and EU method C.2. The study included a limit test and a range-finding test. In the limit test, twenty daphnids (in four replicates of five) were exposed to a nominal loading rate of 1000 mg/L for 48 hours while a second group of 20 daphnids (in four replicates of five) was exposed to test dilution water (M4) only (control solution).
In the range-finding test, three groups of 20 daphnids (in four replicates of five) were subjected to nominal loading rates of 1, 10, 100 and 1000 mg/L for a period of 48 hours. The solutions remained unchanged for the duration of the test. Immobilization at each loading rate was recorded at 0, 24 and 48 hours. Chemical analysis was undertaken to measure the concentration of the test item, based on the peroxide, in limit test solution (loading rate of 1000 mg/L) throughout the test. In the limit test, immobilizations were 0 % in the control and the limit test solution (1000 mg/L nominal) after 48 hours.
In the range-finding test, no immobilization was observed at 1, 10,100 and 1000 mg/L nominal throughout the test. As the test item was not found to be toxic at the nominal loading rate of 1000 mg/L (limit test solution), chemical analysis was undertaken to measure the concentration of cyclohexylidenebis[tert-butyl] peroxide in this solution. The initial concentration of the test item measured in the limit test solution was 0.598 mg/L. The test item was not stable under the experimental conditions since its concentration fell below 80 % of the initial value during the test. The measured concentration was 0.0415 mg/L after 24 hours, corresponding to 7% of the initial concentration, and < 0.0394 mg/L (limit of quantification) after 48 hours. The measured concentration of the test item in the limit test solution at the beginning of the test (0.598 mg/L) was retained for data interpretation since a geometric mean of measured concentrations throughout the test could not be determined.
Hence, the highest concentration resulting in no immobilization at 48 hours was >= 1000 mg/L expressed as initial loading rate, corresponding to 0.598 mg/L expressed as actual concentration. The 48-hour EC50 of cyclohexylidenebis[tert-butyl] peroxide in a static test system is > 1000 mg/L expressed as initial loading rate (EL50), corresponding to 0.598 mg/L expressed as actual concentration (measured concentration at the beginning of the test in the saturated solution obtained from this loading rate of 1000 mg/L) for Daphnia magna. Under test conditions, it can be considered that the peroxide has no toxic effect at the maximum achievable solubility to daphnia.
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