Registration Dossier
Registration Dossier
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EC number: 206-884-6 | CAS number: 393-11-3
Endpoint summary
Administrative data
Description of key information
The acute oral toxicity of the test item 2-Nitro-5-amino bentsotrifluoride ( 4-Nitro-3-(trifluoromethyl)aniline) was evaluated in female Sprague Dawley rats according to OECD 423, EC 2008/440/EC B.1 tris, US EPA OPPTS 870.1100 guidelines and in compliance with GLP. The test substance induced mortality in the rat following oral administration of a single dose at levels of 2000 and 300 mg/kg. Main clinical sings after 2000 mg/kg were reduced activity, ataxia and moribund status and after 300 mg/kg reduced activity, lethargy, prone posture and moribund status. Gross pathology examination showed abnormal colour and/or abnormal contents in the parts of Gastrointestinal track, Abdominal cavity, Cranial cavity and Thoracic cavity at dose 2000 mg/kg. At 300 mg/kg dose decedent animals showed yellow stainign of the urogenital region. No mortality or other relevant signs of toxicity were observed following dosing at 50 mg/kg. The results suggest the LD50 to be greater than 50 mg/kg but lower than 300 mg/kg bw and indicate the classification of Acute Oral Toxicity Category 3.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 300 mg/kg bw
- Quality of whole database:
- Guideline GLP study
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Study result Oral LD50 > 50 - < 300 mg/kg bw.
Classification for acute oral toxicity required under Regulation EC 1272/2008:
Classification: Category 3
Signal word: Danger
Hazard statement: H301 Toxic if swallowed
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