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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Link to relevant study records
Reference
Endpoint:
in vitro gene mutation study in bacteria
Type of information:
experimental study
Adequacy of study:
other information
Study period:
Last Revision Date: 1992/12/15
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Key result
Species / strain:
S. typhimurium TA 98
Metabolic activation:
without
Genotoxicity:
negative
Key result
Species / strain:
S. typhimurium TA 100
Metabolic activation:
without
Genotoxicity:
negative
Key result
Species / strain:
S. typhimurium TA 98
Metabolic activation:
with
Genotoxicity:
negative
Conclusions:
Ames test performed on Salmonella Typhimurium (strains TA98, TA100) was both negative with both metabolic activation and without.
Executive summary:

Available data are inconclusive for the assessment of the germ cell mutagenicity of the substance.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Genetic toxicity in vivo

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

For the substance are available in vitro mutagenicity tests (bacterial reverse mutation tests); in these tests the substance is not considered “mutagenic”. Moreover, QSAR Toolbox  has not identified any structural alert this property.

 

Overall,  the hazard class "germ cell mutagenicity" is judged as inconclusive.