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EC number: 928-726-1 | CAS number: 1179913-28-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From May 23, 2016 to May 26, 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: OECD guidance document no. 23
- Version / remarks:
- Guidance document on aquatic toxicity testing of difficult substances and mixtures (adopted Dec. 2000)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Batch no.: #210162718
Composition: Reaction products of linseed-oil fatty acids, 4,4'-methylendiphenyldiglycidylether with neodecanoic fatty acid, oxiranylmethylester
Purity: 100 % as per definition of UVCB
Appearance: brown liquid - Analytical monitoring:
- yes
- Remarks:
- DOC
- Details on sampling:
- At the start and at the end of the test, the content of the test substance in the test solutions was determined using measurement of dissolved organic carbon (DOC). The measured concentration based on DOC measurement was very low caused by the low solubility of the test substance. Nevertheless, the increase of DOC showed the presence of the test substance in the test solutions. Therefore, the determination of the biological results was based on the geometric mean of the measured concentrations. Geometric mean is calculated by multiplicationof the n participating concentrations and taking the nth root. Additionally the determination of the biological results was based on nominal concentration.
- Details on test solutions:
- The water-accommodated fraction (WAF) prepared for the test was done by weighing the nominal load 100.6 mg/L, adding the corresponding amount of dilution water and shaking vigorously for 25 hours. The resulting solution was filtrated through 0.45 μm nylon filters.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Species: Daphnia magna; Variety: STRAUS; Strain: Berlin; Sex: female; Age: between 0 and 24 hours
- Vessels: preserving glasses, nominal volume 2 L; Medium M4-Medium (recipe of ELENDT); Food: unicellular green algae (Desmodesmus subspicatus); Medium renewal: twice a week; Photo period: 16/8 hours, using neon tubes; Temperature 20 ± 2 °C. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 250 mg CaCO3/L
- Test temperature:
- 19.1 – 21.3 °C
- pH:
- 7.8
- Dissolved oxygen:
- 8.3 (O2-Concentration in mg/L)
- Salinity:
- -
- Conductivity:
- -
- Nominal and measured concentrations:
- 100 mg/L (nominal)
3.26 mg/L (measured) - Details on test conditions:
- - Treatments: 4 vessels, each containing 20 mL test solution and 5 Daphnia
- Blank control: 4 vessels, each containing 20 mL dilution water and 5 Daphnia - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate K2Cr2O7 (CAS No. 7778-50-9)
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 3.3 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: limit of solubility during this study
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 3.3 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: limit of solubility during this study
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 3.3 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: limit of solubility during this study
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Because no toxicity was observed, no calculation of the biological with the help of validated software was performed. The results based on the mean of the measured concentrations which represent the limit of solubility during the conditions of this study and additionally on the nominal concentration.
- One valid experiment was performed. 20 Daphnia were exposed to the test substance for the treatment for 48 hours in a static test system. None of the animals were immobilised in the blank control and in the treatment of 100 mg/L (nominal). - Results with reference substance (positive control):
- The 24h-EC50 value was determined as1.6 mg/L, lying within the demanded range of 0.6 – 1.7 mg/L stated in the guideline.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the study conditions, none of the animals were immobilised after a 48 h exposure to the test substance at a concentration of 100 mg/L (nominal) or 3.3 mg/L (measured). Therefore, the 48hEC50 and NOEC (in Daphnia magna) were established at >3.3 and ≥3.3 mg/L (measured).
- Executive summary:
A study was conducted to determine the short-term toxicity to aquatic invertebrates of the test substance according to OECD Guideline 202, EU Method C.2. Daphnia magna were exposed for 48 h to water accommodated fractions (WAFs) prepared at loading rates of 0 (control) and 100 mg/L (limit test) under static conditions. Mobility of the Daphnia was evaluated after 24 and 48 h and samples for analytical dose verification were taken from the test groups at test start and end. Analysis of the samples indicated very low dissolved organic carbon (DOC) concentrations due to low water solubility, which increased after 48 h. Therefore, the determination of the results was based on the geometric mean of the measured concentrations. None of the animals were immobilised after a 48 h exposure to the test substance at the limit concentration. The EC50 value of the positive control was also found to be within the range stated in the guideline. All other validity criteria were met. Therefore, under the study conditions, the 48h EC50 and NOEC for Daphnia magna was determined to be >3.3 and 3.3 mg/L (measured concentration), which corresponds to a nominal concentration of 100 mg/L (Muckle, 2016).
Reference
Description of key information
The 48h EC50 and NOEC for Daphnia magna were established at >3.3 and 3.3 mg/L, based on mean measured concentration.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 3.3 mg/L
Additional information
A study was conducted to determine the short-term toxicity to aquatic invertebrates of the test substance according to OECD Guideline 202, EU Method C.2.Daphnia magna were exposed for 48 h to water accommodated fractions (WAFs) prepared at loading rates of 0 (control) and 100 mg/L (limit test) under static conditions. Mobility of the Daphnia was evaluated after 24 and 48 h and samples for analytical dose verification were taken from the test groups at test start and end. Analysis of the samples indicated very low dissolved organic carbon (DOC) concentrations due to low water solubility, which increased after 48 h.Therefore, the determination of the results was based on the geometric mean of the measured concentrations. None of the animals were immobilised after a 48 h exposure to the test substance at the limit concentration. The EC50 value of the positive control was also found to be within the range stated in the guideline. All other validity criteria were met. Therefore, under the study conditions, the 48h EC50 and NOEC for Daphnia magna were determined to be >3.3 and 3.3 mg/L (measured concentration) respectively, which corresponds to a nominal concentration of 100 mg/L (Muckle, 2016).
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