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EC number: 246-905-6 | CAS number: 25371-55-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- Modified Beuhler Design
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2600 (Skin Sensitisation)
- Deviations:
- no
- GLP compliance:
- yes
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- A Buehler assay was conducted for R&D purposes in 2004 and in the interest of animal welfare it was considered unethical to run a LLNA.
Test material
- Reference substance name:
- Methyl hydrogen octadecylphosphonate
- EC Number:
- 246-905-6
- EC Name:
- Methyl hydrogen octadecylphosphonate
- Cas Number:
- 25371-55-5
- Molecular formula:
- C19H41O3P
- IUPAC Name:
- methoxy(octadecyl)phosphinic acid
- Reference substance name:
- Octadecylphosphonic acid
- EC Number:
- 225-216-4
- EC Name:
- Octadecylphosphonic acid
- Cas Number:
- 4724-47-4
- Molecular formula:
- C18H39O3P
- IUPAC Name:
- octadecylphosphonic acid
- Reference substance name:
- Dimethyl octadecylphosphonate
- EC Number:
- 246-904-0
- EC Name:
- Dimethyl octadecylphosphonate
- Cas Number:
- 25371-54-4
- Molecular formula:
- C20H43O3P
- IUPAC Name:
- dimethyl octadecylphosphonate
- Test material form:
- solid
Constituent 1
impurity 1
impurity 2
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- male/female
- Details on test animals and environmental conditions:
- Animals were housed individually in suspended stainless steel cages. All housing and care were based on the standards recommended by the Guide for hte Care and Use of Laboratory Animals. PMI Cerified Guinea Pig Chow and municipal tap water treated by reverse osmosis was available ad libitum throughout the studyENVIRONMENTAL CONDITIONS:Room Temperature: 18-22 ° CRelative Humidity: 36-68% Light Cycle: 12-hour light /12-hour dark cycleVentilation: 10-15 air changes /hour
Study design: in vivo (non-LLNA)
- No. of animals per dose:
- 10/sex/dose
- Details on study design:
- Ten male and ten females were topically treated with 2.% MMOP in propylene glycol, once per week for three consecutive weeks. Following a two-week rest period, a challenge was performed wherbu the 20 test and ten previously untreated ontrol guinea pigs were topically treated with 0.1 % w/v MMOP in propylene glycol. Challenge responses in the test animals were compared with those of the challenge control animals
- Challenge controls:
- Ten previously untreated (naive) challenge control guinea pigs were topically treated with 0.1% w/v MMOP in propylene glycol.
- Positive control substance(s):
- yes
- Remarks:
- A α-Hexyclcinnamaldehyde (HCA)
Study design: in vivo (LLNA)
- Vehicle:
- propylene glycol
- Concentration:
- Topical application: 2.5% MMOP in propylene glycolChallenge application: 0.1% w/v MMOP in propylene glycol
- No. of animals per dose:
- 10 animals/sex/dose
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.1%
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 0.1%
- No. with + reactions:
- 1
- Total no. in group:
- 20
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 0.1%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 0.1%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- positive control
- Dose level:
- 2.5%
- No. with + reactions:
- 10
- Total no. in group:
- 10
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 0/20 animals were sensitized during the course of this study indicating that sensitization has not been induced after eposure to the test item.
- Executive summary:
The dermal sensitization potential of MMOP was evaluated in Hartley-derived albino guinea pigs. Ten male and tem female guinea pigs were topically treated with 2.5% w/v MMOP in propylene glycol, once per week, for three consecutive weeks. Following a two-week rest period, a challenge was performed whereby the 20 test and 10 previosuly untreated (naive) challenge control guinea pigs were topically treated with 0.1% w/v MMOP in propylene glycol. Challenge responses in the test animals were compared with those of the challenge control animals. A α-Hexylcinnamaldehyde positive control group consisting of ten HCA test and ten HCA control guinea pigs was included in the study. The HCA test animals received a 5.0% w/v HCA in ethanol for induction and 2.5% and 1.0% HCA in acetone for challenge.
Following challenge, dermal reactions in the test animals were limited to score of 0 to ± at the 24 -hour scoring interval. At the 48 hour scoring interval a score of 1 was noted in 1/20 test animals. All remaining test and challenge control animals had score of 0 to ±.
Following challenge with HCA, 10/10 HCA test animals were noted to have a stronger dermal response than was observed in the corresponding HCA control animals. The results of the HCA positive control study demonstrated that a valid test was performed and indicated that the test design would detect potential contact sensitizers.
0/20 test animals had a positive response 24 hours after challenge but by the 48 hour observation point 1/20 test animals had a positive reaction. Under the classification criteria documented in the Classification, labelling and packaging regulation (EC)2382/2008, this substance is not a skin sensitizer.
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