Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 246-905-6 | CAS number: 25371-55-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February 20, 2004 - March 3, 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methyl hydrogen octadecylphosphonate
- EC Number:
- 246-905-6
- EC Name:
- Methyl hydrogen octadecylphosphonate
- Cas Number:
- 25371-55-5
- Molecular formula:
- C19H41O3P
- IUPAC Name:
- methoxy(octadecyl)phosphinic acid
- Reference substance name:
- Octadecylphosphonic acid
- EC Number:
- 225-216-4
- EC Name:
- Octadecylphosphonic acid
- Cas Number:
- 4724-47-4
- Molecular formula:
- C18H39O3P
- IUPAC Name:
- octadecylphosphonic acid
- Reference substance name:
- Dimethyl octadecylphosphonate
- EC Number:
- 246-904-0
- EC Name:
- Dimethyl octadecylphosphonate
- Cas Number:
- 25371-54-4
- Molecular formula:
- C20H43O3P
- IUPAC Name:
- dimethyl octadecylphosphonate
- Test material form:
- solid
Constituent 1
impurity 1
impurity 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Animals were held individually in suspended stainless steel cages. All housing and care were based on teh standards recommended by the Guide for the Care and Use of Laboratory Animals. Food and water was provided ad linitum to the animals throughout the study.Environmental Conditions:Room tempeature: 22°CRelative humidity: 47-63%Light cycle: 12-hour ligt/ 12-hour dark cycleRoom ventilation: 10-15 air changes/ hour
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 100% (unchanged)
- Duration of treatment / exposure:
- 3 minutes, 1-hour and 4-hours
- Observation period:
- 7 days
- Number of animals:
- 3 males
- Details on study design:
- On day -1, the animals chosen for use on the primary skin irrtiation study had the fur removed from the dorsal area of the trunk using animal clippers. The following day (day 0), the test article was applied to a small area of intact skin on each test animal for either 3 minutes, 1 hour or 4 hours. In all cases the test article was moistoned with 0.5mL of deionized water to form a paste and then administerd inder the gauze patch. The gauze was held in place with a non-irritating tape.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 3-Minute
- Score:
- 0.45
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 3 minute
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 1
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 0.11
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 4 hour
- Score:
- 1.6
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 4 hour
- Score:
- 0.22
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- The 3-minute exposure to the test article produced slight erythem on 2/3 test sites at the 24 hour observation point. Dermal irritation resolved completley on 1/3 test sites by 48 hours and on the remaining site by the end of the 7 day observation period.The 1- hour exposure to the test article prodiuced well-defined erythema on 2/3 sites and slight oedema on 1/3 test sites by the 24-hour scoring interval. The dermal irritation resolved completely on both test sites by study day 7The 4-hour expoure to the test article produced very slight to well-defined erythem on 3/3 test sites and slight oedmea on 2/3 test sites by the 24-hour scoring interval. The dermal irritation resolved compleltley on all test sites by day 7.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 (mild irritant) based on GHS criteria
- Conclusions:
- Under the conditions of the test, MMOP did not produce evidence of corrosion during the 3 minute, 1-hour or 4-hour exposure periods.
- Executive summary:
The potential irritant and/or corrosive effects of MMOP were evaluated on teh skin of New Zealand White rabbits, Initially one animal was dosed. Since corrosivity was not observed in this animal, dosing was continued with two additional animals. Each rabbit received three 0.5 g of the test article as a single dermal application. The doses were held in contact with the skin undersemi occlusive conditions for an exposure time of three minutes, one hour and four hours, respectively.
The 3 minute exposure to the test article produced slight erythema on 2/3 test sites by the 24 -hour scoring interval. The dermal irritation resolved completely on 1/3 test sites bu the 48 -hour scoring interbal and on the remaining test site by study day 7.
1 -hour exposure to the test article produced well defined erythema on 2/3 test sites and slight edema on 1/3 test sites by the 24 -hour scoring interval. The dermal irritation resolved completley on both test sites by day 7.
4 -hour exposure to the test article produced very slight to well defind erythema on 3/3 test sites and slight oedema on 2/3 test sites by tehe 24 -hour scoring interval. The dermal irritation resolved completley on 3/3 test sites by study day 7.
Therefore, under the conditions of the test, MMOP did not produce evidence of corrosion during the 3 minute, 1 -hour or 4 -hour exposure period. It is a GHS Category 3 Mild Skin Irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.