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Diss Factsheets
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EC number: 609-870-1 | CAS number: 40835-18-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well-documented, scientifically acceptable study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Reference substance 001
- Cas Number:
- 153812-94-3
- Test material form:
- liquid
- Details on test material:
- Name of the test substance used in the study report: Beta-Formylcrotonsaeuremethylester
Purity: > 95%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Acclimatization period: at least one week
Animals of a comparable weight were used.
Animal identification using cage cards (group identification).
Five animals per cage (type: stainless steel wire mesh cages, DK-III).
They were housed in fully air-conditioned rooms with a room temperature of 20 - 24°C and a relative humidity of 30 - 70%. The day/night rhythm was 12 h light and 12 h darkness.
The animals were offered a standardized animal laboratory diet as well as tap water ad libitum. Food depreviation 16 hours before test substance administration (water was available ad libitum).
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- The test substance was sensitive to hydrolysis.
Form of administration: solution
Concentrations used: 9.28, 20 and 40 g/100 ml
Administration volume: 5 ml/kg - Doses:
- 464, 1000 and 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Observation period: 14 days
Recording of signs and symptoms several times on the day of test substance administration (at least once each workday). Check for moribund and dead animals twice each workday and once on public holidays.
Withdrawal of food about 16 hours before sacrifice with CO2; then necropsy with gross-pathological examination. Necropsy of all animals that die as soon as possible. - Statistics:
- slope factor calculated accord to Finney, DJ, probit analysis, Cambridge University Press, 3rd ed., 1971
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 410 mg/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 660 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 200 mg/kg bw
- Mortality:
- Males: 464 and 1000 mg/kg: no deaths; 2000 mg/kg: 4/5 after 14 days
Females: 464 mg/kg: no deaths; 1000 mg/kg: 1/5 after 14 days; 2000 mg/kg: 5/5 after 14 days - Clinical signs:
- Dyspnea, apathy, abnormal position (females only), staggering, piloerection, diarrhea, salivation (females only), poor general state
- Body weight:
- Mean body weight male animals: 185.3 g at study start, 258.3 g after 13 days
Mean body weight female animals: 183.3 g at study start, 212.0 g after 13 days - Gross pathology:
- Animals that died: glandular stomach: multiple hemorrhagic erosions in some animals; hyperemia of mucosa with edema in most of the animals.
Sacrificed animals: forestomach: wall thickening, intra-abdominal adhesions (1000 and 2000 mg/kg); low dose level: no pathologic findings noted.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.