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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
no
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
photometric method
Type:
Pow
Partition coefficient:
ca. 0.221
Temp.:
20 °C
pH:
5.83
Type:
log Pow
Partition coefficient:
ca. -0.663
Temp.:
20 °C
pH:
5.83
Details on results:
The values are average Pow and average log Pow.

At 96 hours values reached equilibrium, and so this value was considered for final calculations making duplicate determinations of every ratio o/w. Concentration of mother solution: W1 = 0.0419 g / 100ml = 0.4190 g/l

Ratio o/w Water phase c (g/l) n-octanol phase c (g/l) Pow  log Pow Average log Pow
70/30 0.3736 0.1058 0.2833 -0.547759 -0.6553
70/30 0.3901 0.0674 0.1727 -0.762816
50/50 0.3373 0.0817 0.2421 -0.616088 -0.6888
50/50 0.3571 0.0619 0.1732 -0.761427
30/70 0.2714 0.0633 0.2332 -0.632320 -0.6456
30/70 0.2771 0.0608 0.2194 -0.658788

pH of the test solution: 5.83
Average Pow 0.2206 Average log Pow -0.6632
Std. Dev Pow 0.0113 Std. Dev log Pow 0.023
Conclusions:
Pow =0.2206 and log Pow =-0.6632 at 20 °C and pH=5.83
Executive summary:

Partition coefficient test was carried out according to the OECD Guideline 107. The average Pow value is 0.2206 and the average log Pow value is -0.6632. These results are obtained at 20 °C and pH = 5.83.

Description of key information

-0.6632 at 20 °C and pH 5.83

Key value for chemical safety assessment

Log Kow (Log Pow):
-0.663
at the temperature of:
20 °C

Additional information

Partition coefficient test was carried out according to the OECD Guideline 107. The average Pow value is 0.2206 and the average log Pow value is -0.6632. These results are obtained at 20 °C and pH = 5.83.