Registration Dossier
Registration Dossier
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EC number: 211-617-1 | CAS number: 674-82-8
Endpoint summary
Administrative data
Description of key information
Oral:
- male rats, LD50: 613 mg/kg bw (limited data only)
- rats, LD50: 540 mg/kg bw (limited data only)
Inhalation:
- male/female rats, LC50: 0.94 mg/L
- male rats, LC50: 0.82 mg/L
- female rats, LC50: 1.01 mg/L
Dermal:
- male rabbits, LD50: 3100 mg/kg bw (limited data only)
- male rabbits, LD50: 6730 mg/kg bw (limited data only)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 540 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 820 mg/m³ air
Additional information
Except for acute inhalation toxicity only very restricted information is available in rats and rabbits for the acute toxicity of Diketene. The lowest oral LD50determined was 540 mg/kg bw rats. The LC50 (4-hour) for Diketene for male rats as most sensitive species was established at 0.82 mg /L and in two unreliable publications a dermal LD50 of 3100 mg/kg bw/d in rabbits is reported. All results are shown in the “Short description of key information” field
Justification for classification or non-classification
Due to the findings described above (LD50 oral in rats 540 mg/kg bw, LC50 inhalation in male rats 0.82 mg/L and LD50 dermal in rabbits 3100 mg/kg bw/d) Diketene has to be classified as
- acute orally toxic: Xn, R22 - harmful if swallowed; Hazard category 4, H302 - harmful if swallowed
- toxic by inhalation: T, R23 - toxic by inhalation; Hazard category 2, H330 - fatal if inhaled
according to the criteria laid down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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