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Diss Factsheets
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EC number: 241-442-6 | CAS number: 17418-58-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- The complete read across justification is detailed in section 13. Source study has reliability 1.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Test temperature:
- 20 °C.
- Details on study design: HPLC method:
- The determination was carried out using the HPLC screening method, designed to be compatible with EU method C19 (2008) and OECD guidelines 121 (2001).
The test system utilized a high performance liquid chromatograph. A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used.
The sample, dead time and reference standard solutions were injected in duplicate using the following HPLC parameters:
HPLC System: Agilent Technologies 1200 series
Column: Luna Cyano 5 μm 100 Å (150 x 4.6 mm id)
Column temperature: 20 ºC
Mobile phase: methanol: purified water (55:45 v/v)
pH of mobile phase:7.0
Flow-rate: 1.0 ml/min
Injection volume: 10 μl
UV detector wavelength: 210 nm dead time and standards & 520 nm sample - Analytical monitoring:
- yes
- Type:
- Koc
- Value:
- 21 700 dimensionless
- Temp.:
- 20 °C
- Type:
- log Koc
- Value:
- 4.34 dimensionless
- Temp.:
- 20 °C
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The adsorption coefficient (Koc) of the test item has been determined to be 2.17 x 10E4, log10 Koc 4.34. These values indicate that the test item will demonstrate immobility in the environment.
- Executive summary:
A key study was performed to determine the adsorption of test substance according to OECD guideline 121.
The test item has no dissociation constants relevant to this test, therefore manipulation of the mobile phase pH was unnecessary. Testing performed at approximately neutral pH with the test item in a non-ionised form. As the slope of the calibration curve for the reference standards showed good first order correlation and as the retention times between duplicate injections for each solution were consistent, the HPLC method was considered valid for the determination of adsorption coefficient.
The adsorption coefficient (Koc) of the test item has been determined to be 2.17 x 104, logKoc 4.34. These values indicate that the test item will demonstrate immobility in the environment.
Reference
Description of key information
Log Koc = 4.34 at 20 °C.
Key value for chemical safety assessment
- Koc at 20 °C:
- 21 700
Additional information
No experimental data on Disperse Red 060 was available, nevertheless, based on the physicochemial properties, the substance can be expected to have a low potential for adsorption (log Kow < 3). In order to support this evaluation a read across approach was followed. Details are attached in section 13.
HPLC method based on OECD guideline 121 and EU method C.19.
Data on Similar Substance 01 was used to assess the adsorption/desorption potential of the test item, as the two substances show similar chemical structure and properties. The two species are anthraquinone rings substituted by polar and apolar groups, leading to low water solubility and similar partition coefficients, i.e. log Kow values in the range of ca. 1.8 - 2.3.
Test item has no dissociation constants relevant to this test, thus manipulation of the mobile phase pH was unnecessary. Test was performed at approximately neutral pH with the test item in a non-ionised form. As the slope of the calibration curve for the reference standards showed good first order correlation and retention times between duplicate injections for each solution were consistent, the HPLC method was considered valid for the determination of adsorption coefficient.
The adsorption coefficient (Koc) of the test item was determined to be 2.17 x 104, log Koc 4.34. These values indicate that the test item will demonstrate immobility in the environment.
[LogKoc: 4.34]
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