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EC number: 265-183-3 | CAS number: 64742-80-9 A complex combination of hydrocarbons obtained from a petroleum stock by treating with hydrogen to convert organic sulfur to hydrogen sulfide which is removed. It consists of hydrocarbons having carbon numbers predominantly in the range of C11 through C25 and boiling in the range of approximately 205°C to 400°C (401°F to 752°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 475 (Mammalian Bone Marrow Chromosome Aberration Test)
- GLP compliance:
- not specified
- Type of assay:
- chromosome aberration assay
Test material
- Reference substance name:
- 64742-80-9
- Cas Number:
- 64742-80-9
- IUPAC Name:
- 64742-80-9
- Reference substance name:
- Hydrodesulfurised middle distillate (CAS# 64742-80-9)
- IUPAC Name:
- Hydrodesulfurised middle distillate (CAS# 64742-80-9)
- Test material form:
- other: low viscosity liquid hydrocarbon
- Details on test material:
- - Hydrodesulphurised middle distillate
- Sample API 81-09
- Name of test material (as cited in study report): API 81-09 (CAS# 64742-80-9)
- Physical state: clear, pale straw coloured liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Duration of treatment / exposure:
- single IP dose. Phase dsacrifice at 6, 24 and 48 hrs post dose
- Frequency of treatment:
- single dose
- Post exposure period:
- 6, 24 or 48 hrs post dose
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.3, 1.0 and 3.0 g/kg
Basis:
nominal conc.
- No. of animals per sex per dose:
- 5 animals per dose group for each phased sacrifice time
Examinations
- Tissues and cell types examined:
- harvested bone marrow cells
- Details of tissue and slide preparation:
- bone marrow cells harvested 3 hrs after colchicine administration. Slides satined with Geisma
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Any other information on results incl. tables
There was no evidence of a treament-related effect.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
There was no evidence of a treatment related genetic toxicity effect. - Executive summary:
Three groups of 5 Sprague Dawley rats of each sex were given a single dose test material (3, 1 and 0.3 g/kg) intraperitoneally. One group of each treatment and sex was killed 6, 24 and 48 hours after treatment, having been injected with colchicine two or three hours previously. The bone
marrow was removed, fixed, stained with Giemsa and examined for chromosomal aberrations. Negative and positive control groups were also included. There was no evidence of a treatment related genetic toxicity effect.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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