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EC number: 246-910-3 | CAS number: 25376-45-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The Key study (Hanstveit and Oldersma, 1995) carried out according to OECD Guideline 201 and GLP on the freshwater algae Desmodesmus
subspicatus, gave a 72h ErC50 of 140mg/L and a 72h-EbC50 of 39mg/L for 2,6-TDA.
Key value for chemical safety assessment
Additional information
Available data on toxicity to aquatic algae
Four bibliographic references with reliability (2) reported experimental results on toxicity to aquatic algae. Those experimental results were obtained by tests performed according to OECD guideline 201 (Freshwater Alga and Cyanobacteria, Growth inhibition Test), or to experimental procedures similar to this guideline (i.e. DIN 38412), or according to an acceptable scientific methodology. Ecotoxicity values like 72h-EC50 and 96h-EC50 are reported for two freshwater algae species.
Ecotoxicity data on Selenastrum capricornatum
Experimental results were obtained with the 96 -h freshwater green alga growth inhibition tests. The results on Selenastrum capricornatum are the following:
2,4 -TDA: 96h-EbC50=78.1 µmol/L (=9.53 mg/L) (nominal concentration)
2,6-TDA: 96h-EbC50=466.2 µmol/L (=56.9 mg/L) (nominal concentration)
Ecotoxicity data on Desmodesmus subspicatus
Experimental results were obtained by tests performed according to OECD guideline 201 or equivalent to this one. Ecotoxicity values (72h-EC50) measured on a freshwater species (Desmodesmus subspicatus) are the following:
2,4-TDA: 72h-EbC50=126mg/L (nominal concentration)
2,6-TDA: 72h-EyC50=23mg/L ; 72h-ErC50=140mg/L ; 72h-EbC50=39mg/L (measured concentration, GLP)
Conclusion
Sensitivity of the two algae species to both isomers is different. Based on the experimental study conducted according to OECD guideline 201 under GLP, 72h-ErC50 of 140 mg/L and 72h-EbC50 of 39 mg/L are identified as key information for toxicity to freshwater aquatic algae.
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