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EC number: 248-666-3 | CAS number: 27813-02-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LC50 fish (96h): > 100 mg/l
EC50 Daphnia magna (48h): > 143 mg/l
NOEC Daphnia magna (21d): 45.12 mg/l
EC50 Algae (72h): > 97.2 mg/l (growth rate)
NOEC Algae (72h): 97.2 mg/l (growth rate)
Additional information
Aquatic toxicity studies with methacrylic acid, monoester with propane-1,2-diol were conducted in fish, invertebrates, and algae.
For fish, one acute study with the golden orfe (Leuciscus idus melanotus) was available for assessment. The LC50 was >493 mg/L and based on an acute 48-hour static exposure (Hüls AG, 1987). Though the exposure was conducted for 48 hours instead of the standard 96-hour exposure, LC50 96h was assessed based on a read across approach with 2-hydroxyethyl methacrylate (CAS 868-77-9). A read across approach was performed with the structurally very similar substance 2-hydroxyethyl methacrylate. Although log Pow of hydroxypropyl methacrylate (0.97) is slightly higher than that of 2-hydroxyethyl methacrylate (0.42), the hydrophobicity of both substances is low and does not expect a strong impact on aquatic toxicity. The Environmental Agency of Japan has performed two limit tests with 2-Hydroxyethyl methacrylate: a standard test acc. OECD 203 for 96 h and a prolonged test acc. OECD 204 for 14 d. In both test EC 50 was > 100 mg/l. (E.A Japan, 1997)
For invertebrates, one acute and one chronic study with Daphnia magna are available for assessment. The EC50 was >143 mg/L, based on the acute 48-hour semi-static limit test exposure (Mitsubishi, 2004). Based on the chronic 21-day semi-static exposure, the NOEC for reproduction was 45.2 mg/L (Mitsubishi, 2005).
For the algal species, one study with Pseudokirchnerella subcapitata is available for assessment. The EC50 and NOEC for the freshwater species were both >97.2 mg/L, the highest concentration tested and based on growth rate following 72-hours of exposure.
Toxicity to microorganisms testing is waived for hydroxypropyl methacrylate since it is classified as readily biodegradable at an application concentration (100 mg/L), which is greater than the predicted environmental concentration (PEC) in the influent of the sewage treatment plant (STP). EC10/NOEC of 100 mg/l is used for assessement.
Long-term testing in fish is waived for hydroxypropyl methacrylate shows that the PEC/PNECaqua ratio for the aquatic environment is <1, indicating no need for further information or testing.
Taken together, the lowest aquatic toxicity value for hydroxypropyl methacrylate was the NOEC of 45.2 mg/L, based on the 21 -day chronic toxicity test with Daphnia magna.
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