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EC number: 701-480-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Complex metal containing substance
Water solubility of the substance is poor (for metal constituents)
Several high quality studies demonstrate no negative effects .An LDs 50 of > 2000 mg/kg bw were assessed. Copper slag is considered non toxic via oral, dermal and inhalation route.
Classification based on rules for mixtures
In vitro bio-accessability in artificial biological fluids ( gastric and sweat)
Key value for chemical safety assessment
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- discriminating dose
Additional information
The copper slag is a complex metal containing substance (UVCB). It mainly contains iron silicate and silicates of aluminum and calcium. Traces of metals exist in metal, mineral form or included in silicate phases.
Substance is used in massive, granular or powder form with varying particle size distribution (IUCLID section 4.5). Routes for exposure to consider are therefore oral and inhalation.
Copper slag is inorganic solid poorly soluble in water. It is not likely to penetrate though organic media. Absorption of copper slag through the skin is therefore considered to be of less significance than absorption through the respiratory and gastrointestinal routes
The following test data were obtained:
- The acute oral effects - LD50 > 2000 mg/kg ( 3 studies)
- The acute dermal effects - LD50 > 2000 mg/kg ( 2 studies)
These data are used for classification.
Additionally classification was derivedbased on rules for mixtures:
- The calculated Oral Acute toxicity estimate of the mixture is > 2000 mg/kg
- The calculated Inhalation Acute toxicity estimate of the mixture is > 5mg/l
Results from calculated classification are further supported (WoE) by consideration of physical chemical properties of the UVCB substance.
Chemistry and mineralogy of the slag (see IUCLID section 4.23 chemical and mineralogical characterization) were taken into account.
Water solubility (IUCLID section 4.8) and Sequential dissolutions (IUCLID 4.23 Chemical assays) furthermore confirmed species present and their solubility behavior.
Justification for classification or non-classification
Acute oral classification
Based on the available acute oral toxicity data ( i.e LD50> 2000 mg/kg ) and calculated Oral Acute toxicity estimate ( ATE >2000 mg/kg ) copper slag is not classified as hazardous for acute toxicity by the oral route.
Acute inhalation classification
No test data on acute inhalation toxicity are available. The calculated Inhalation Acute toxicity estimate of the mixture is > 5mg/l thus copper slag is not classified as hazardous for acute toxicity by the inhalation route.
Acute dermal classification
Consideration of available acute dermal toxicity data (i.e. LD50>2000 mg/kg) leads to the conclusion that copper slag does not require classification for acute lethal effects.
Copper slag is an inorganic solid poorly soluble in water. It is not likely to penetrate through skin in any significant quantity and so would therefore not cause any toxic effects following dermal exposure. Furthermore, negligible metal release in in-vitro bio-accessibility test in artificial sweat fluid was observed (0.021 to 0.036 µg Ni/cm2/week)
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