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EC number: 233-046-7 | CAS number: 10025-87-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Older guideline-comparable study reported in summary form
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Class B poison test
- GLP compliance:
- no
- Remarks:
- : study pre-dates GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Phosphoryl trichloride
- EC Number:
- 233-046-7
- EC Name:
- Phosphoryl trichloride
- Cas Number:
- 10025-87-3
- Molecular formula:
- Cl3OP
- IUPAC Name:
- phosphoroyl trichloride
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Five rabbits (three male and two female) New Zealand albino rabbits in the weight range of between 1.9 kg and 2.5 kg were used in this experiment.
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- No details specified
- Duration of exposure:
- 24 hour exposure
- Doses:
- Four dose levels were used in this study: 398, 631, 1000 and 1580 mg/kg bw.
- No. of animals per sex per dose:
- Three male and two females
- Control animals:
- no
- Details on study design:
- One male rabbit was administered with the 398 mg/kg bw dose, one female rabbit received the 631 mg/kg bw dose, one male and one female rabbit received the 1000 mg/kg bw dose and one male rabbit received the 1580 mg/kg bw dose.
- Statistics:
- No additional information
Results and discussion
- Preliminary study:
- None
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 000 mg/kg bw
- Remarks on result:
- other: 1/2 deaths at this dose level
- Mortality:
- No deaths were recorded at dose levels of 398 and 631 mg/kg bw, where as one death (1/2) was recorded at the 1000 mg/kg bw level and one death was recorded at the 1580 mg/kg bw level
- Clinical signs:
- other: Signs of toxicity were recorded as follows: weight loss (two to three days in survivors), increasing weakness, collapse and death
- Gross pathology:
- Lung and liver hyperaemia, enlarged gall bladder, kidney discolouration in one instance and gastrointestinal inflammation. After 14 days the viscera of the survivors appeared normal
- Other findings:
- No additional information
Any other information on results incl. tables
No deaths were recorded at dose levels of 398 and 631 mg/kg bw, where as one death (1/2) was recorded at the 1000 mg/kg bw level by day 4 and one death was recorded at the 1580 mg/kg bw level by day 2 after dosing. Signs of systemic toxicity (weight loss (in survivors), increasing weakness, collapse and death) were observed.
Dose level mg/kg bw |
Average initial weight |
Mortalities / Dosed |
Time of Mortality |
|||
Male |
Female |
Male |
Female |
Combined |
||
398 |
2.5 |
- |
0/1 |
- |
0/1 |
- |
631 |
- |
2.0 |
- |
0/1 |
0/1 |
- |
1000 |
2.1 |
2.0 |
0/1 |
1/1 |
1/2 |
4 days |
1580 |
1.9 |
- |
1/1 |
- |
1/1 |
2 days |
Applicant's summary and conclusion
- Conclusions:
- Based on the mortality of 1/2 animals at this dose level, the acute dermal LD50 value is estimated to be 1000 mg/kg bw.
- Executive summary:
Phosphoryl trichloride was applied (occlusion and duration not specified) to five rabbits (three male and two female) at dose levels of 398 (1), 631 (1), 1000 (2) and 1580 mg/kg bw (1). Deaths occurred at the 1000 mg/kg bw (1/2) by day four after dosing, and 1580 mg/kg bw (1/1) by day 2 after dosing.
Based on the results of this study, the acute dermal LD50 of phosphoryl trichloride is estimated to be 1000 mg/kg bw.
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