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EC number: 233-046-7 | CAS number: 10025-87-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Older guideline-comparable study reported in summary form
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- The test method is comparable to the withdrawn OECD TG 401
- GLP compliance:
- no
- Remarks:
- : the study pre-dates GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Phosphoryl trichloride
- EC Number:
- 233-046-7
- EC Name:
- Phosphoryl trichloride
- Cas Number:
- 10025-87-3
- Molecular formula:
- Cl3OP
- IUPAC Name:
- phosphoroyl trichloride
- Test material form:
- liquid: volatile
- Details on test material:
- The test material 'MCTR-191-77' is stated to be a colourless, transparent, viscous and volatile liquid.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- A total of 50 male and female rats weighing between 200 and 300 grams, were fasted for approximately 24 hours prior to the administration of the test material.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- The test material sample 'MCTR-191-77' (=phosphoryl trichloride) was administered on a mg/kg basis as a 10% solution in corn oil.
- Doses:
- The dose levels of the test substance included in the study were 50, 100, 200, 300 and 400 mg/kg bw.
- No. of animals per sex per dose:
- Ten animals (male and female; not speciifed further)
- Control animals:
- no
- Details on study design:
- The animals were observed at 1, 3, 6, 24, 72 and daily thereafter for a total of 14 days if survival allowed and then killed, autopsied and observed for gross pathological organ changes.
- Statistics:
- None required
Results and discussion
- Preliminary study:
- None
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 110 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 91 - < 129
- Remarks on result:
- other: Calculated according to the method of Miller & Tainter, 1944.
- Mortality:
- Two deaths were recorded after rats were administered with the 50 mg/kg dose, 4 deaths were recorded following the 100 mg/kg dose, 9 deaths were recorded following the 200 mg/kg dose, 9 deaths were recorded following the 300 mg/kg dose and 10 deaths were recorded following the 400 mg/kg dose
- Clinical signs:
- other: Decreased locomotor activity, piloerection, ptosis, suspected blood around the eyes, loss of righting reflex and death. Chronic pulmonary disease was revealed at 50, 100 and 200 mg/kg body weight. Normal body activity returned within 7 days in all surviv
- Gross pathology:
- Autopsies revealed lung fused to the rib cage in rats adminstered with the 50 mg/kg dose level. At 100 mg/kg there appeared to be lung fused to the rib cage and filled with a white mass, with irregular thickening on the cardiac mucosa
- Other findings:
- None
Any other information on results incl. tables
Distribution of Mortality
Dose (mg/kg bw) |
Deaths |
Hour |
Observation Day |
|||||||||||||||
1 |
3 |
6 |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
||
50 |
2/10 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
100 |
4/10 |
0 |
0 |
0 |
1 |
2 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
200 |
9/10 |
1 |
7 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
300 |
9/10 |
4 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
400 |
10/10 |
4 |
5 |
0 |
1 |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The acute oral LD50 of phosphoryl trichloride in the rat was found to be 110 mg/kg bw under the conditions of this study. Based on these results, 'MCTR-191-77' is classified with Acute Tox. 3 (H301, Toxic if swallowed) according to GHS criteria.
- Executive summary:
Groups of ten male and female Sprague-Dawley rats were gavaged with single doses of phosphoryl trichloride (10% in corn oil) at dose levels of 50, 100, 200, 300 or 400 mg/kg bw and observed for 14 days. Gross necropsy was performed on all animals.
Thirty-four deaths were recorded following administration of the test substance, with the majority of deaths occurring in the higher dose level groups. The following signs of toxicity were observed: decreased locomotor activity, piloerection, ptosis, suspected blood around the eyes, loss of righting reflex and death. Chronic pulmonary disease was revealed at dose levels of 50, 100 and 200 mg/kg bw. Normal activity returned within seven days in all surviving animals. Autopsies revealed lung fused to the rib cage in rats administered 50 mg/kg bw. At 100 mg/kg bw there appeared to be lung fused to the rib cage and filled with a white mass, with irregular thickening of the cardiac mucosa
The acute oral LD50 in the rat was calculated to be 110 mg/kg bw under the conditions of this study.
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