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Diss Factsheets
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EC number: 205-391-3 | CAS number: 140-01-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published data, information on methods and results is sufficient to make an assessment.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Alleviation of the two-cell block of ICR mouse embryos by polyaminocarboxylate metal chelators
- Author:
- Matsukawa, T.
- Year:
- 2 002
- Bibliographic source:
- 65-71. [Reproduction (Cambridge, England)]
Materials and methods
- Type of study / information:
- Alleviation of the two-cell block of ICR mouse embryos by polyaminocarboxylate metal chelators
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- None specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- N-carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid)
- EC Number:
- 200-652-8
- EC Name:
- N-carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid)
- Cas Number:
- 67-43-6
- IUPAC Name:
- N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine
- Details on test material:
- - Name of test material (as cited in study report): Diethylenetriaminepentaacetate (DTPA)
Constituent 1
Results and discussion
Any other information on results incl. tables
The order of stability constants of polyaminocarboxylates for transitionmetal ions such as zinc, copper and iron isas follows: NTA EDDA < EGTA < EDTA < DTPA. Addition of 10 or 100 µmol polyaminocarboxylates 1-1 to the medium significantly enhanced the development of most one-cell embryos (66-88%) beyond thetwo-cell stage compared with that(<25%) in medium without polyaminocarboxylates. Although EDDA, EDTA and DTPA at 10 µmol1-1induced the development of most one-cell embryos to the four-cell stage and beyond, a higher concentration (100 µmol 1-1) of NTA and EGTA was required to obtain a similar result. Therefore, the ability of polyaminocarboxylates to overcome the two-cell block is not correlated with their potency to chelate transition metal ions. In contrast, the non-polyaminocarboxylatesdipicolinic acid and deferoxamine, at 10 and 100µmol I-1,did not have the same effect. Taken together, the results indicate that the ability of polyaminocarboxylates to overcome the two-cell block in embryo development is due to some common feature or features other than the ability to chelate transition metal ions.
Applicant's summary and conclusion
- Conclusions:
- The present study demonstrated that polyaminocarboxylates with different stability constants for transition metal ions have an ability to alleviate the two-cell block in ICR mouse zygotes; however, this ability was not necessarily correlated with the stability constants of the polyaminocarboxylates. Accordingly, although it remains to be clarified how EDTA and other polyaminocarboxylates alleviate the two-cell block in ICR mouse embryos, it seems likely that some common structural feature of polyaminocarboxylates, other than their ability to chelate metal ions, is required to promote embryonic development, especially beyond the second cell cycle division.
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