Registration Dossier
Registration Dossier
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EC number: 931-974-3 | CAS number: 1231880-35-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Sulfuric acid, mono-C12-13-alkyl esters, sodium salts
- EC Number:
- 295-101-1
- EC Name:
- Sulfuric acid, mono-C12-13-alkyl esters, sodium salts
- Cas Number:
- 91783-23-2
- IUPAC Name:
- 91783-23-2
- Details on test material:
- - Name of test material (as cited in study report): trade name
- Physical state: no data
- Analytical purity: 26.76%
- Lot/batch No.: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 880, 1040, 1260 and 1500 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 230 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 063 mg/kg bw
- Mortality:
- Male rats:
at 880, 1040mg/kg bw: no mortalities 0/5
at 1260 mg/kg bw: 3/5 animals died within 14 days
at 1500 mg/kg bw: 5/5 animals died within 14 days
Female rats:
at 880 mg/kg bw: no mortalities 0/5
at 1040 mg/kg bw: 2/5 animals died within 14 days
at 1260 mg/kg bw: 5/5 animals died within 14 days
at 1500 mg/kg bw: 5/5 animals died within 14 days - Clinical signs:
- not stated
- Body weight:
- not stated
- Gross pathology:
- not stated
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Classification:
DSD: Xn, R22 Harmful if swallowed
GHS: Acute Oral Category 4
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