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EC number: 231-439-8 | CAS number: 7550-35-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988-01-20 to 1988-02-03
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- Status and principle of method according OECD guideline 404 as adopted in 1981.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Lithium bromide
- EC Number:
- 231-439-8
- EC Name:
- Lithium bromide
- Cas Number:
- 7550-35-8
- Molecular formula:
- BrLi
- IUPAC Name:
- lithium bromide
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazleton Research Animals, Inc., Denver, Pennsylvania, USA
- Age at study initiation: young adults
- Weight at study initiation: 3.10 - 3.31 kg
- Housing: individually in stainless steal cages
- Diet: Purina High Fiber Rabbit Chow 5326, ad libitum
- Water: fresh tap water, ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 68 - 71
- Humidity (%): 33 - 59
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Vehicle:
- other: the test substance was moistened with saline
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 14 days
- Number of animals:
- 3 animals
- Details on study design:
- TEST SITE
- Area of exposure: scapular to the pelvic region
- Type of wrap if used: cheesecloth bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Test sites were wiped with clean gauze moistened with methanol, then rinsed with tap water.
- Time after start of exposure: four hours
SCORING SYSTEM: Draize J. H. et al. (1944)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 2.2
- Max. score:
- 8
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48 hours
- Score:
- 2.2
- Max. score:
- 8
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 2
- Max. score:
- 8
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24, 72 hours
- Score:
- 2.1
- Max. score:
- 8
- Irritant / corrosive response data:
- Two rabbits exhibited slight to mild erythema and slight to moderate edema over the test sites during the study. One rabbit had severe erythema, edema, eschar, exfoliation and burned areas over the sites. Irritation effects on two of the rabbits had not resolved by day 14 of the study.
- Other effects:
- The skin of one animal appeared to be burned.
Any other information on results incl. tables
- The following results are based on results obtained on one of the two application sites on each animal; the site where the effects were more pronounced:
Animal 1 - Erythema average score (24, 48, 72 hours): Scoring 2 (out of 4) - Not reversible in 14 days
Animal 2 - Erythema average score (24, 48, 72 hours): Scoring 0 (out of 4)
Animal 3 - Erythema average score (24, 48, 72 hours): Scoring 3 (out of 4) - Not reversible in 14 days
Animal 1 - Edema average score (24, 48, 72 hours): Scoring 1.6 (out of 4) - Reversible in 4 days
Animal 2 - Edema average score (24, 48, 72 hours): Scoring 0 (out of 4)
Animla 3 - Edema average score (24, 48, 72 hours): Scoring 2 (out of 4) - Reversible in 7 days
Animal 3 also exhibited eschar, exfoliation and test sites which appeared to be burned.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of the study performed with New Zealand White rabbits and under the conditions of this study, the test substance lithium bromide was regarded to be irritant to the skin.
- Executive summary:
Three New Zealand White rabbits were treated topically on each of two test sites which were previously clipped free of hair. 0.5 g of lithium bromide anhydrous was placed in contact with each test site. The test sites were covered with gauze patches and the trunk of each animal was wrapped with a sheet of cheesecloth. The test material was in contact with the skin for 4 hours, after which the animals were unwrapped and the test material removed. Approximately 30 minutes after the end of the exposure period, the test sites were scored for irritation using the method of Draize. The test sites were scored daily thereafter for 14 days. Slight to severe erythema and slight to severe edema were noted on the test sites during the study. One rabbit also exhibited eschar, exfoliation and appeared to be burned on the test sites. Irritation on two of the rabbits had not resolved by day 14 of the study. The primary irritation index was 2.1. Under the conditions of this study and based on the Primary Irritation Index, the test material was evaluated to be irritating to intact skin when applied topically to New Zealand White rabbits. (FMC, 1988)
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