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EC number: 221-499-3 | CAS number: 3121-61-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given. No details on analytical purity of the test substance. Limited details on inhalation exposure as well as on test animals and environmental conditions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- no details on analytical purity of the test substance; limited details on inhalation exposure as well as on test animals and environmental conditions
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-methoxyethyl acrylate
- EC Number:
- 221-499-3
- EC Name:
- 2-methoxyethyl acrylate
- Cas Number:
- 3121-61-7
- Molecular formula:
- C6H10O3
- IUPAC Name:
- 2-methoxyethyl acrylate
- Details on test material:
- - Name of test material (as cited in study report): Methyl Cellosolve Acrylate, 2-Methoxyethoxy Propenoate
- Physical state: clear liquid
- Analytical purity: no data
- Other: Sample No. 31-126; Reg. No. 511-01-4353, received from Union Carbide Corporation, Chemicals and Plastics Division, South Charleston, WV
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Remarks on duration:
- pre-study: 15 min - 1 h
- Concentrations:
- pre-study:
1 h: 1576 ppm corresponding to 8.5 mg/L
30 min: 1810 ppm corresponding to 9.8 mg/L
15 min: 1966 ppm corresponding to 10.6 mg/L
main study:
4 h: 1000 ppm corresponding to 5.4 mg/L
4 h: 500 ppm corresponding to 2.7 mg/L
4 h: 250 ppm corresponding to 1.4 mg/L
Dose calculation was based on a molecular weight of 130.14 g/mol and a molar volume of 24.1 L/mol (at 20 °C). - No. of animals per sex per dose:
- 6
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- ca. 2.7 mg/L air
- Based on:
- test mat.
- 95% CL:
- ca. 1.9 - ca. 3.8
- Exp. duration:
- 4 h
- Remarks on result:
- other: based on a molecular weight of 130.14 g/mol and a molar volume of 24.1 L/mol (at 20 °C)
- Mortality:
- pre-study:
1 h (8.5 mg/L): all animals died
30 min (9.8 mg/L): 1 animal died
15 min (10.6 mg/L): no animals died
main study:
4 h (5.4 mg/L): all animals died
4 h (2.7 mg/L): 3 animals died
4 h (1.4 mg/L): no animal died - Clinical signs:
- other: Within 30 min exposure to 9.8 mg/L of the test substance, animals showed laboured breathing at 10 min. Animals exposed to 8.5 and 10.6 mg/L did not show clinical signs of toxicity during the 1 h or 15 min exposure period, respectively. After 4 h exposure
- Body weight:
- All surviving animals showed a weight gain after exposure to the test substance at different concentrations.
- Gross pathology:
- After exposure to the test substance for 30 min and 1 h, rats dying prior to study termination had bright red livers and gas-filled intestinal tract. Rats surviving to study termination after 15 and 30 min exposure had no remarkable findings.
After 4-h exposure, rats dying prior to scheduled termination had slight haemorrhage of lungs and blood in intestines. For rats surviving until scheduled termination, 2 of 3 rats at 2.7 mg/L had areas of focal consolidation scattered throughout the lungs. All others showed nothing remarkable. - Other findings:
- - Other observations:
1 h (8.5 mg/L): irritation of eyes at 10 min; irritation of extremities at 35 min
30 min (9.8 mg/L): irritation of eyes at 5 min; irritation of extremities at 25 min
15 min (10.6 mg/L): irritation of eyes at 5 min; irritation of nose at 10 min
4 h (5.4 mg/L): irritation of eyes at 20 min; irritation of extremities at 25 min
4 h (2.7 mg/L): irritation of eyes at 5 min; irritation of extremities at 1-1/2 h
4 h (1.4 mg/L): irritation of eyes; irritation of extremities at 2-1/2 h
Exposure to 1.4 mg/L or approximately 10% of saturated vapour for a few minutes may cause ocular irritation. A longer exposure to this vapour concentration may cause skin irritation. Experimentation with rats indicates that prolonged exposure to this vapour could lead to irritation of the mucous membranes and skin and pulmonary injury.
Any other information on results incl. tables
Table 1. Acute inhalation toxicity
Exposure time |
Dose |
Toxicological results* |
Observation of clinical signs |
Time of death |
Mortality (%) |
Pre-study |
|||||
1 h |
8.5 |
6/0/6 |
--- |
Days 1 and 2 |
100 |
30 min |
9.8 |
1/6/6 |
at 10 min |
Day 1 |
17 |
15 min |
10.6 |
0/0/6 |
--- |
--- |
0 |
Main study |
|||||
4 h |
5.4 |
6/6/6 |
at 2 h |
Days 1 and 2 |
100 |
4 h |
2.7 |
3/6/6 |
at 4 h |
Days 1 and 3 |
50 |
4 h |
1.4 |
0/0/6 |
at 4 h |
--- |
0 |
LC50 = 2.7 mg/L |
*first number = number of dead animals
second number = number of animals with clinical signs
third number = number of animals used
Table 2. Body weight changes
Exposure time |
Dose [mg/L] |
Weight Change* |
Pre-study |
||
1 h |
8.5 |
N/A |
30 min |
9.8 |
+++++ |
15 min |
10.6 |
++++++ |
Main study |
||
4 h |
5.4 |
N/A |
4 h |
2.7 |
+++ |
4 h |
1.4 |
++++++ |
+ = animals with weight gain
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- CLP: Acute Inhal 3, H331
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