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Diss Factsheets
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EC number: 221-499-3 | CAS number: 3121-61-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given. Only animals who died during the observation period were necropsied. Lack of data on test substance (no analytical purity).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- only dead animals were necropsied; no histopathology
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-methoxyethyl acrylate
- EC Number:
- 221-499-3
- EC Name:
- 2-methoxyethyl acrylate
- Cas Number:
- 3121-61-7
- Molecular formula:
- C6H10O3
- IUPAC Name:
- 2-methoxyethyl acrylate
- Details on test material:
- - Name of test material (as cited in study report): Sipomer MCA
- Physical state: clear liquid
- Analytical purity: no data
- Lot No.: E169H8
- Density: 1.01 g/cm³
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Taconic Farms
- Weight at study initiation: 200-300 g
- Fasting period before study: 18 h
- Housing: during the test period the animals were housed individually in stainless steel wire bottomed cages.
- Diet: Fisher Rat Chow; ad libitum
- Water: ad libitum
- Acclimation period: at least 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.0-22.2
- Humidity (%): 45-55
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- DOSAGE PREPARATION: 1.0 mL test material was diluted to 10.0 mL with water.
MAXIMUM DOSE VOLUME APPLIED: 0.6 mL/kg bw - Doses:
- 0.25 mL/kg bw corresponding to 252.5 mg/kg bw
0.35 mL/kg bw corresponding to 353.5 mg/kg bw
0.50 mL/kg bw corresponding to 505.0 mg/kg bw
0.55 mL/kg bw corresponding to 555.5 mg/kg bw
0.60 mL/kg bw corresponding to 606.0 mg/kg bw
Based on the density of Sipomer MCA: 1.01 g/cm³ - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Frequency of weighing: after fasting; surviving animals were weighed at the end of the 14-day observation period.
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs - Statistics:
- The defined oral LD50 was calculated by the Litchfield-Wilcoxin method of Probit Analysis (J. Pharmacology and Experimental Therapeutics 96: 99-115, 1949).
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 404 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 343.4 - 464.6
- Mortality:
- 252.5 mg/kg bw: no animals died
353.5 mg/kg bw: 2 males and 2 females died
505.0 mg/kg bw: 2 males and 3 females died
555.5 mg/kg bw: 4 males and 4 females died
606.0 mg/kg bw: 5 males and 5 females died - Clinical signs:
- other: No clinical signs were noted.
- Gross pathology:
- Necropsy revealed pulmonary haemorrhages (only dead animals were necropsied). Incidences:
353.5 mg/kg bw: 1 female
505.0 mg/kg bw: 1 male
555.5 mg/kg bw: 4 males, 2 females
606.0 mg/kg bw: 2 males, 1 females
Any other information on results incl. tables
Table 1. Acute oral toxicity.
Dose |
Toxicological results* |
Duration of clinical signs |
Time of death |
Mortality (%) |
Males |
||||
252.5 |
0/0/0 |
--- |
--- |
0 |
353.5 |
2/0/5 |
--- |
Day 2 |
40 |
505.0 |
2/0/5 |
--- |
Day 3 - Day 4 |
40 |
555.5 |
4/0/5 |
--- |
Day 2 |
80 |
606.0 |
5/0/5 |
--- |
Day 2 |
100 |
Females |
||||
252.5 |
0/0/0 |
--- |
--- |
0 |
353.5 |
2/0/5 |
--- |
Day 3 |
40 |
505.0 |
3/0/5 |
--- |
Day 2 - Day 3 |
60 |
555.5 |
4/0/5 |
--- |
Day 2 - Day 3 |
80 |
606.0 |
5/0/5 |
--- |
Day 2- Day 4 |
100 |
LD50 = 404 mg/kg bw |
* first number = number of dead animals
second number = number of animals with clinical signs
third number = number of animals usedApplicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- CLP: Acute Oral 4, H302
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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