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Diss Factsheets
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EC number: 206-764-3 | CAS number: 373-44-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
skin sensitisation:
The test substance Octamethylenediamine was investigated upon its skin sensitising potential on young Dunkan-Hartley albino guinea pigs according to the procedure of the Haskell Laboratory, Newark, Delaware (Henry, 1987). The study was conducted according to CPA Good Laboratory Practice Regulations on shaved, intact skin of 10 male animals. p-Phenylenediamine was used as positive control. The test substance concentrations in the challenge phase were 0.4 % and 4 % (w/v) as suspensions in distilled water. The primary irritation phase was conducted by applying and lightly rubbing of the test suspensions and scoring was done 24 and 48 h after this dermal application. Two days later the induction phase was initiated with the same animals and consisted of a series of 4 sacral intradermal injections (1 time per week) of 0.1 mL of a 1.0 % (w/v) test suspension. After about 24 h skin responses were evaluated. The challenge started two weeks later by applying and lightly rubbing 4 % and 0.4 % of the test material suspension onto separate sites of shaved, intact shoulder skin. In 6 of 10 animals moderate erythema was recorded and 2 of 10 guinea pigs had mild erythema at the 4 % concentration site by 24 hours. After 48 hours, 1 guinea pig exhibited erythema and edema and 6 guinea pigs had moderate erythema. Positive control substance produced a significant response in 10 of 10 animals which is evident for valid test system. As overall result, at challenge, the test substance produced a significant score increase in 7 animals over the reponse observed during the induction phase. The study results clearly show the skin sensitizing potential of the test substance but are not suited for subclassification into skin sensitization Category 1A or 1B.
Migrated from Short description of key information:
dermal sensitisation study in guinea pigs, Hasekell Laboratories 1987: sensitising
Justification for classification or non-classification
Octamethylenediamine was classified as skin sensitizer Category 1 (EU: R43; H317) according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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