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Diss Factsheets
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EC number: 207-330-6 | CAS number: 462-95-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Lab not following OECD guidelines or GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Internal SOP: TA300, TA120
- Deviations:
- not specified
- Principles of method if other than guideline:
- dose level tested: 5000, 2500 and 1250 mg/kg. Administrated as received. method of calculation: Weil method
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Diethoxymethane
- EC Number:
- 207-330-6
- EC Name:
- Diethoxymethane
- Cas Number:
- 462-95-3
- Molecular formula:
- C5H12O2
- IUPAC Name:
- diethoxymethane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CRL: CD (SD) BR
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5000, 2500 and 1250 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 536 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 400 - 5 209
- Mortality:
- 4/5 individuals (male and females) at 5000 mg/kg.
None at the other dose levels - Clinical signs:
- other: Ataxia: at all doses, immediate to 1 hour Weaknes slight to severe: at all doses, immediate to 4 hours Prostration: at 5000 mg/kg, 1hour to 4 hours Normal state: at all doses, day 1 to day 14
- Gross pathology:
- none
Any other information on results incl. tables
CLINICAL SIGNS |
|||
SIGN |
DOSE(mg/kg) |
TIME |
SEX |
Ataxia |
5000, 2500, 1250 |
Immediate to1 Hour
|
M,F |
Weakness-Slightto Severe |
5000, 2500, 1250 |
Immediate to 4 Hours
|
M,F |
Prostration |
5000 |
1 Hour to 4 Hours |
M,F |
Normal |
5000, 2500, 1250 |
Day 1 to Day14
|
M,F |
The test material was, at most, slightly toxic by the oral route. Abnormal clinical signs included slight to severe weakness at all dose levels, ataxia at the first hour after dosing, and prostration up to four hours after dosing at the high dose level. Eight of ten animals administered the high (5000 mg/kg) dose died within 24 hours, but all survivors appeared clinically normal from Day 1 through the observation period. The cause of death in animals dying after exposure to the test material was not determined. Treatment-related changes in those animals dying within one day of dosing included congestion, edema, and hemorrhage of the glandular gastric mucosa and reddish blue urine in the urinary bladder. No abnormalities related to administration of the test material were noted in animals surviving the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The Gavage LD50 of Ethylal on rats is 3536 mg/kg which is superior to the CLP cut off values of 2000 mg/kg
- Executive summary:
The Gavage LD50 of Ethylal on rats is 3536 mg/kg which is superior to the CLP cut off values of 2000 mg/kg
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