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Diss Factsheets
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EC number: 461-870-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- other: Expert Statement
- Adequacy of study:
- supporting study
- Study period:
- 18 May 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The expert statement report compares the relevant toxicity between the free acid and salt forms with regards to biological and toxicological significance and read across terms. The full comparative report is appended below.
Data source
Materials and methods
- Type of study / information:
- Expert Review of the Comparison Between Reactive Yellow 201 and Everzol Yellow GSP Related to Potential Biological Effects.
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- The paper comprises of an Expert Review of the Comparison Between Reactive Yellow 201 and Everzol Yellow GSP Related to Potential Biological Effects.
- GLP compliance:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 461-870-9
- EC Name:
- -
- Cas Number:
- 795275-80-8
- Molecular formula:
- C14H14N4Na2O9S3
- IUPAC Name:
- Sodium 2,4-diamino-5-(4-(2-sulfoxyethanesulfonyl)phenylazo)b enzenesulfonate
- Details on test material:
- Not applicable.
Constituent 1
Results and discussion
Any other information on results incl. tables
From the information presented it is clear that in any biological system (and hence for the safety evaluation of human or environmental hazard assessment) there will be no difference between the qualitative effects of Reactive Yellow 201 and Everzol Yellow GSP. However, if a risk assessment is being performed based on the exposure to the test item on a weight basis (e.g. mg/kg bodyweight) then there is a small difference between the two materials.
In biological terms, the activity of each material will be identical on a molar basis, but the molecular weight of Reactive Yellow 201 is 522.49 (assuming the di-sodium salt) and the molecular weight of Everzol Yellow GSP is 478.52. So for all toxicology experiments performed on Everzol Yellow GSP, any numeric values such as NOAEL or LC50, to calculate the equivalent value for Reactive Yellow 201, the numeric value should be multiplied by (522.49/478.52) which is all cases will make only a small difference, the heavier molecule being slightly "safer" than Everzol Yellow GSP on a numeric scale. There would in practice be little or no real difference between the two molecules under most experimental situations.
In the production of both Everzol Yellow GSP and Reactive Yellow 201, the method of synthesis is identical up to the point of final isolation. The pH of the solution at isolation will affect which salt is produced, the dry pure product will either possess the Na or the H group on the charged oxygen. As described in the report, as soon as the material is dissolved again, the equilibrium will be reached almost instantly and at an acid pH the ionised form will be
predominant.
In summary, all biological effects would be the result of dissolved material, and when in an aqueous solution, there is no difference between the biological activities of Everzol Yellow GSP and Reactive Yellow 201 on a molar basis.
Applicant's summary and conclusion
- Conclusions:
- There is no toxicological or biological significance between Reactive Yellow 201 and Everzol Yellow GSP.
- Executive summary:
In summary, all biological effects would be the result of dissolved material, and when in an aqueous solution, there is no difference between the biological activities of Everzol Yellow GSP and Reactive Yellow 201 on a molar basis.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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