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Diss Factsheets
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EC number: 233-153-9 | CAS number: 10045-95-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Genetic toxicity in vitro:
Bacterial reverse mutation assay:
Thompson (2013) performed an Ames (preliminary toxicity test, plate incorporation assay and preincubation method) test with S typhimurium strains TA1535, TA1537, TA98 and TA100 and Escherichia coli strain WP2uvrA in the presence and absence of metabolic activation (10% S9).
Following test concentrations were applied in triplicate:
Preliminary toxicity test: 0, 0.15, 0.5, 1.5, 5, 15, 50, 150, 500, 1500 and 5000 µg/plate (neodymium trinitrate as active ingredient) Mutation test - experiment 1:
0, 5, 15, 50, 150, 500, 1500 and 5000 µg/plate (neodymium trinitrate as active ingredient)
0, 6, 18, 60, 181, 604, 1811 and 6035 µg/plate (based on the test item (including a water content of 20.7%))
Mutation test - experiment 2:
0, 5, 15, 50, 150, 500, 1500 and 5000 µg/plate (neodymium trinitrate as active ingredient)
0, 6, 18, 60, 181, 604, 1811 and 6035 µg/plate (based on the test item (including a water content of 20.7%))
The test item caused a visible reduction in the growth of the bacterial background lawn and/or substantial reductions in revertant colony frequency for all of the tester strains in the presence and absence of S9-mix at 5000 µg/plate in each experiment. Negative and positive controls responded adequately. No significant increases in the frequency of revertant colonies were recorded for any of the strains of bacteria, at any dose level either with or without metabolic activation or exposure method.
Justification for selection of genetic toxicity endpoint
There is only one study available for this endpoint.
Short description of key information:
Genetic toxicity in vitro:
In an Ames test according to OECD Guideline 471, EU Method B.13/14 and EPA OPPTS 870.5100 (Thompson, 2013), neodymium trinitrate proved to be negative for mutagenicity with and without metabolic activation.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the available information, the substance does not need to be classified for genotoxicity under CLP or DSD.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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