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EC number: 233-153-9 | CAS number: 10045-95-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
Conclusion on classification
Acute toxicity:
Short-term toxicity studies are available on fish and daphnids, with L/EC50 ranging from 1 to 10 mg/L, meaning that neodymium trinitrate is toxic to these species. No data is available on algae for the reasons explained in IUCLID section 6.1.5. Briefly, all available data from algal growth inhibition studies performed with rare earth compounds have provided evidence that adverse effects on algal growth are due to phosphate deprivation as a result of the strong interaction of rare earths with phosphate rather than a direct toxic effect as a result of exposure to bioavailable dissolved rare earths. For this reason, it was concluded that there is no scientific added value in performing further algal toxicity studies with rare earth compounds. As a result, the environmental hazard classification is based on data available on the two other trophic levels (i.e. fish and daphnids).
It has to be noticed that the available acute toxicity study on fish was judged not entirely reliable as performed in conditions minimizing the toxicity. Indeed, precipitation cannot be ruled out as no analytical monitoring was performed, and based on the knowledge aquired from the water solubility study (see IUCLID section 4.8), solubility is known to be significantly decreased when the pH is adjusted to environmental values (i.e. pH=6.98). In spite of these conditions which could have led to an underestimation of toxicity, some adverse effects were observed, giving a 96h-LC50 of 2 mg/L, thus relatively close to the 1-mg/L acute classification threshold under CLP. As a matter of safety, it was thus preferred not to rule out these results.
This precautionary principle is further supported by data available on other rare earth trinitrates. Indeed, in more recent acute toxicity studies in fish with analytical monitoring and taking care of applying a design to maintain dissolved rare earth concentrations as much as possible, the 96h-LC50 were below 1 mg/L (but still above 0.1 mg/L; e.g. cerium trinitrate, lanthanum trinitrate, yttrium trinitrate, erbium trinitrate).
Based on the above considerations, it was found appropriate to classify neodymium trinitrate in aquatic acute toxicity category 1 (H400) with an acute M factor of 1.
Chronic toxicity:
Long-term toxicity studies are available on fish and daphnids. In fish, the endpoint the most sensitive to exposure to neodymium trinitrate was the post-hatching survival with a 33d-LC10 of 0.081 mg/L. In daphnids, reproduction and body length were equally sensitive to exposure to neodymium trinitrate with a 21d-EC10 of 0.18 mg/L for both endpoints. No data is available on algae for the reasons explained in IUCLID section 6.1.5. and above summarized.
Considering the LC10 value obtained in the most sensitive species (i.e. fish) and in the absence of data on the rapid environmental transformation of neodymium, neodymium trinitrate has to be classified in aquatic chronic toxicity category 1 (H410) with a chronic M factor of 1.
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