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EC number: 270-336-2 | CAS number: 68425-16-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- There is no guideline method available but the methods used in the report are deemed as appropriate for the intraperitoneal route of exposure.
- GLP compliance:
- no
Test material
- Reference substance name:
- Polysulfides, di-tert-nonyl
- EC Number:
- 270-336-2
- EC Name:
- Polysulfides, di-tert-nonyl
- Cas Number:
- 68425-16-1
- Molecular formula:
- C78H110O6S5
- IUPAC Name:
- bis(1,1,2,3,3-pentamethylbutyl)trisulfane
- Details on test material:
- Test compound: TPS 37
Chemical name: di-t-nonyl polysulfide
CAS no.: 68425-16-1
Source: Elf Aquitaine
Batch: no data
Total sulfur: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: OFA
- Weight at study initiation: 140-170 g
- Housing: cage with dimensions 37.5 x 23.5 x 16 cm
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C
- Humidity (%): 50%
- Air changes (per hr): 6
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: none
- Doses:
- 3500, 4500, and 6000 mg/kg
- No. of animals per sex per dose:
- 30
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 828 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 3 350 - <= 4 375
- Mortality:
- There were deaths in all 3 dose groups. After exposure to 6000 mg/kg, there were no survivors.
- Clinical signs:
- One hour after treatment with 3500 mg/kg TPS 37,reduced spontaneous activity, apathy, prostration, piloerection, and slight closing of the palpebral slit was observed. Six hours after treatment, the same signs were observed. On day 2, just piloerection was observed and on day 3, piloerection was only observed in one female. All other survivors appeared normal.
One hour after treatment with 4500 mg/kg TPS 37, low spontaneous activity, apathy, prostration, piloerection, and closing of the palpebral slit was observed. Six hours after treatment, moribund animals were found. Recovery of survivors began the next day.
The same observations were made when the treatment dose was 6000 mg/kg, but symptoms were more pronounced. - Body weight:
- There was an increase in body weight throughout the study period.
- Gross pathology:
- Not performed
Any other information on results incl. tables
MORTALITY:
Dose (mg/kg) |
Males |
Females |
3500 |
0/5 |
4/5 |
4500 |
2/5 |
5/5 |
6000 |
5/5 |
5/5 |
LD50: 3828 (3350-4375) mg/kg
Applicant's summary and conclusion
- Conclusions:
- The intraperitoneal LD50 was determined to be 3828 mg /kg bw.
- Executive summary:
In an acute toxicity study Sprague-Dawley rats (5/sex/dose) were administered a single intraperitoneal dose of di-tert-nonyl polysulfide (TPS 37) at doses of 3500, 4500, or 6000mg/kg and subsequently observed for a period of 14 days.
Mortality was observed in male and female rats treated at all doses. One hour after treatment with 3500 mg/kg TPS 37, reduced spontaneous activity, apathy, prostration, piloerection, and slight closing of the palpebral slit was observed. These signs persisted through 6 hours and only piloerection was observed on day 2 post-exposure. On day 3, piloerection was observed in one female rat while all other surviving animals appeared normal. One hour after treatment with 4500 mg/kg TPS 37, low spontaneous activity, apathy, prostration, piloerection, and closing of the closing of the palpebral slit was observed. Six hours after treatment, moribund animals were found. Recovery of survivors began the next day. The same observations were made when the treatment dose was 6000 mg/kg, but symptoms were more pronounced. The intraperitoneal LD50 was determined to be 3828 mg/kg bw.
This study received a Klimisch score of 2 and is classified as reliable with restrictions because it is a well-conducted study that followed valid scientific principles.
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