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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 270-336-2 | CAS number: 68425-16-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 23.5 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 75
- Dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 1 763 mg/m³
- Explanation for the modification of the dose descriptor starting point:
The rat 4-week oral NOAEL of 1000 mg/kg bw/day was used as the starting point.
Modification of dose descriptor
The equivalent rat inhalation NOAEC was derived using route-to-route extrapolation, based on assumption of 100% absorption after ingestion and inhalation.
The inhalatory NOAEC may be calculated as follows:
NOAECinhalation = NOAELoral x 1/sRVrat x ABSoral-rat/ABSinh-human x sRVhuman/wRVhuman
= 1000 x 1/0.38 x 100/100 x 6.7/10
= 1763 mg/m3 (4 -week duration of exposure)
- AF for dose response relationship:
- 1
- Justification:
- Default AF
- AF for differences in duration of exposure:
- 6
- Justification:
- Sub-acute to chronic extrapolation
- Justification:
- AF not required
- AF for other interspecies differences:
- 2.5
- Justification:
- For remaining differences
- AF for intraspecies differences:
- 5
- Justification:
- Default for workers
- AF for the quality of the whole database:
- 1
- Justification:
- Default AF
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.33 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 300
- Dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
The rat 4 -week oral NOAEL of 1000 mg/kg bw/day was used as the starting point.
Modification of dose descriptor
The equivalent dermal NOAEL was derived using route-to-route extrapolation, based on assumption of 100% absorption after ingestion and 100% after skin contact.
The dermal NOAEL may be calculated as follows:
NOAELdermal = NOAELoral x ABSoral-rat/ABSdermal-human
= 1000 x 100/100
= 1000 mg/kg bwt/day (4 -week duration of exposure)
- AF for dose response relationship:
- 1
- Justification:
- Default AF
- AF for differences in duration of exposure:
- 6
- Justification:
- Sub-acute to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- default AF for rats
- AF for other interspecies differences:
- 2.5
- Justification:
- Default AF for remaining differences
- AF for intraspecies differences:
- 5
- Justification:
- Default AF for workers
- AF for the quality of the whole database:
- 1
- Justification:
- Default AF
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Acute Toxicity
A DNEL for acute toxicity need only be derived if an acute hazard leading to acute toxicity (e.g. classified under CLP) has been identified and there is a potential for high peak exposures. If no hazard has been identified, then a DNEL for acute toxicity is unnecessary as the long-term DNEL will be sufficient to ensure that adverse effects do not occur. Di-tert-nonyl polysulfides is neither acutely toxic nor is it an irritant (eye, skin or respiratory tract) and therefore no acute DNELs (systemic or local) have been calculated.
Di-tert-nonyl polysulfides is classified as sensitising to skin, Category 1B, therefore the substance is assessed qualitatively for dermal local acute hazard.
Long-term Systemic Toxicity
The available data indicate a NOAEL of 1000 mg/kg bw/day for di-tert-nonyl polysulfides, based on a 4-week oral toxicity study (Elf Aquitaine Production, 1995) in rats administered di-tert-dodecyl polysulfide (TPS 32), a structural analogue of di-tert-nonyl polysulfides.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 5.8 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 150
- Dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 870 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Dose descriptor
The rat 4 -week oral NOAEL of 1000 mg/kg bw/day was used as the starting point.
Modification of dose descriptor
The equivalent rat inhalation NOAEC was derived using route-to-route extrapolation, based on 100% absorption after ingestion and inhalation.
The inhalatory NOAEC may be calculated as follows:
NOAECinhalation = NOAELoral x 1/sRVrat x ABSoral-rat/ABSinh-human
= 1000 x 1/1.15 x 100/100
= 870 mg/m3 (4-week duration of exposure)
- AF for dose response relationship:
- 1
- Justification:
- default AF
- AF for differences in duration of exposure:
- 6
- Justification:
- sub-acute to chronic extrapolation
- Justification:
- AF not required.
- AF for other interspecies differences:
- 2.5
- Justification:
- default for remaining differences
- AF for intraspecies differences:
- 10
- Justification:
- default for general population
- AF for the quality of the whole database:
- 1
- Justification:
- default AF
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.66 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Dose descriptor
The rat 4 -week oral NOAEL of 1000 mg/kg bw/day was used as the starting point.
Modification of dose descriptor
The equivalent dermal NOAEL was derived using route-to-route extrapolation, based on assumption of 100% absorption after ingestion and 100% after skin contact.
The dermal NOAEL may be calculated as follows:
NOAELdermal = NOAELoral x ABSoral-rat/ABSdermal-human
= 1000 x 100/100
= 1000 mg/kg bwt/day (4 -week duration of exposure)
- AF for dose response relationship:
- 1
- Justification:
- default AF
- AF for differences in duration of exposure:
- 6
- Justification:
- subacute to chronic extrapolation
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- default for rat
- AF for other interspecies differences:
- 2.5
- Justification:
- remaining differences
- AF for intraspecies differences:
- 10
- Justification:
- default for general population
- AF for the quality of the whole database:
- 1
- Justification:
- default AF
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.66 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 1 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Dose descriptor
The rat 4 -week oral NOAEL of 1000 mg/kg bw/day was used as the starting point.
Modification of dose descriptor
The equivalent dermal NOAEL was derived using route-to-route extrapolation, based on assumption of 100% absorption after ingestion by both humans and rats.
The oral NOAEL may be calculated as follows:
NOAELoral = NOAELoral x ABSoral-rat/ABSoral-human
= 1000 x 100/100
= 1000 mg/kg bwt/day (4 -week duration of exposure)
- AF for dose response relationship:
- 1
- Justification:
- default AF
- AF for differences in duration of exposure:
- 6
- Justification:
- sub-acute to chronic extrapolation
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- default for rat
- AF for other interspecies differences:
- 2.5
- Justification:
- default for remaining differences
- AF for intraspecies differences:
- 10
- Justification:
- default for general population
- AF for the quality of the whole database:
- 1
- Justification:
- default AF
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Acute Toxicity
A DNEL for acute toxicity need only be derived if an acute hazard leading to acute toxicity (e. g. classified under CLP) has been identified and there is a potential for high peak exposures. If no hazard has been identified, then a DNEL for acute toxicity is unnecessary as the long-term DNEL will be sufficient to ensure that adverse effects do no occur. Di-tert-nonyl polysulfides is neither acutely toxic nor is it an irritant (eye, skin or respiratory tract) and therefore no acute DNELs (systemic or local) have been calculated.
Di-tert-nonyl polysulfides is classified as sensitising to skin, Category 1B, therefore the substance is assessed qualitatively for dermal local acute hazard.
Long-term Systemic Toxicity
The available data indicate a NOAEL of 1000 mg/kg bw/day for di-tert-nonyl polysulfides, based on a 4 -week oral toxicity study (Elf Aquitaine Production, 1995) in rats administered di-tert-dodecyl polysulfide (TPS 32), a structural analogue of di-tert-nonyl polysulfides.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.