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EC number: 947-406-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from OECD SIDS Initial Assessment Report.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Principles of method if other than guideline:
- Short term toxicity to Pseudokirchneriella subcapitata (algae) study was carried out for 72 hrs. The study was performed according to OECD Guideline 201 (Alga, Growth Inhibition Test).
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Remarks:
- NPOC (non-purgeable organic carbon) analysis was performed.
- Vehicle:
- not specified
- Test organisms (species):
- Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- TEST ORGANISM- Common name: Green algae
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 72 h
- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate was used as positive control in the study.
- Duration:
- 72 h
- Dose descriptor:
- other: ErC50
- Effect conc.:
- 0.83 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: no data
- Duration:
- 72 h
- Dose descriptor:
- other: EbC50
- Effect conc.:
- 0.44 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: Other details not known
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on the effect on growth rate and biomass of the test organism Pseudokirchneriella subcapitata, the 72hr ErC50and EbC50 values of test chemical was determined as 0.83 and 0.44 mg/L, respectively.
- Executive summary:
Short term toxicity to Pseudokirchneriella subcapitata (algae) study was carried out for 72 hrs. The study was performed according to OECD Guideline 201 (Alga, Growth Inhibition Test). The study was based on the effects of the test compound on Pseudokirchneriella subcapitatain a static fresh water system. Pseudokirchneriella subcapitata was used as test organism. Analytical monitoring was done in which the NPOC (non-purgeable organic carbon) analysis was performed. Cultured algae were added to the WAF (Water – Accommodated Fraction) and Potassium dichromate was used as positive control in the study. Based on the effect on growth rate and biomass of the test organism Pseudokirchneriella subcapitata, the72hr-ErC50and EbC50 values of test chemical was determined as 0.83 and 0.44mg/L, respectively.Thus, based on EC50 value, it can be concluded that the substance can be considered as toxic to aquatic organisms and thus can be classifiedas aquatic acute category 1 / chronic 1 as per the CLP classification criteria.
Reference
Description of key information
1. Based on effect on growth rate of the test organism green algae, the 72 hr EC50 and NOEC value was determined to be 0.34 and 0.026 mg/l, respectively and on the basis of AUG, the 72 hr EC50 and NOEC value was determined to be 0.093 and 0.026 mg/l, respectively.
2. Based on the effect on growth rate and biomass of the test organism Pseudokirchneriella subcapitata, the 72hr ErC50and EbC50 values of test chemical was determined as 0.83 and 0.44 mg/L, respectively.
Based on both studies it was concluded that the Reaction mass of 3H-Indolium, 2-[2-[4-(dimethylamino)phenyl]ethenyl]-1,3,3-trimethyl- & acetate was toxic and classified as aquatic acute 1 and chronic 1 as per the CLP criteria.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 0.026 mg/L
Additional information
Data available for the structurally similar read across chemicals has been reviewed to determine the toxicity of aquatic algae and cyanobacteria of the test Reaction mass of 3H-Indolium, 2-[2-[4-(dimethylamino)phenyl]ethenyl]-1,3,3-trimethyl- & acetate. The studies are as mentioned below:
In the first study from authoritative database short term toxicity to green algae study was carried out for 72 hrs. The study was based on the effects of the test compound on green algae in a static fresh water system. Based on effect on growth rate of the test organism green algae, the 72 hr EC50 and NOEC value was determined to be 0.34 and 0.026 mg/l, respectively and on the basis of AUG, the 72 hr EC50 and NOEC value was determined to be 0.093 and 0.026 mg/l, respectively. Thus, based on the EC50 value, it can be concluded that the substance can be considered as toxic to aquatic organisms and thus can be considered to be classified in aquatic acute category 1 / chronic 1 as per the CLP classification criteria.
Similarly second study was from secondary sources in which short term toxicity to Pseudokirchneriella subcapitata (algae) study was carried out for 72 hrs. The study was performed according to OECD Guideline 201 (Alga, Growth Inhibition Test). The study was based on the effects of the test compound on Pseudokirchneriella subcapitata in a static fresh water system. Pseudokirchneriella subcapitata was used as test organism. Analytical monitoring was done in which the NPOC (non-purgeable organic carbon) analysis was performed. Cultured algae were added to the WAF (Water – Accommodated Fraction) and Potassium dichromate was used as positive control in the study. Based on the effect on growth rate and biomass of the test organism Pseudokirchneriella subcapitata, the 72hr-ErC50and EbC50 values of test chemical was determined as 0.83 and 0.44mg/L, respectively. Thus, based on EC50 value, it can be concluded that the substance can be considered as toxic to aquatic organisms and thus can be classified as aquatic acute category 1 / chronic 1 as per the CLP classification criteria.
Based on both studies it was concluded that the Reaction mass of 3H-Indolium, 2-[2-[4-(dimethylamino)phenyl]ethenyl]-1,3,3-trimethyl- & acetate was toxic and classified as aquatic acute 1 and chronic 1 as per the CLP criteria.
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