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EC number: 942-597-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June - July 2013
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 2001
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- other: Separation on HPLC column with Reference Substances - simulates soil and sewage sludge
- Specific details on test material used for the study:
- GR-50-1408 is the Givaudan identification code which was employed for ROSYFOLIA during the early, developmental and testing period.
- Radiolabelling:
- no
- Test temperature:
- HPLC column at 35 °C during separation.
The determination was performed at 35 °C (temperature of the column), but the value obtained above can be considered to represent the value at an unspecified, probably ambient temperature since no mention is made in the guidelines of the temperature at which the tabulated reference substances log Koc values were determined. Adsorption coefficients of the test and reference substances are assumed to vary with temperature in the same way. - Details on study design: HPLC method:
- Reverse phase High Performance Liquid Chromatography on cyanopropyl-modified silicia stationary phase containing lipophilic and polar moieties, is used.
While passing through the column among with the mobile phase the test substance interacts with the stationary phase. As a result of the partitioning between the mobile and stationary phase the test substance is retarded. The dual-composition of the stationary phase having polar and non-polar sites allows for interaction of polar and non-polar groups of a molecule in a similar way as it is the case for organic matter in soil or sewage sludge matrices. This enables the relationship between the retention time on the column and the adsorption coefficient on organic matter to be established.
A solution of the test substance was prepared (10.0 mg in 25 ml methanol/water 55/45 v/v).
After equilibration of the HPLC system, the calibration mixture was injected first, followed by the test chemical solution twice and the calibration mixture again.
Retention times were measures and averaged and the decimal logarithms of the capacity factors k were calculated. The linear regression parameters of the relationship
log Koc = f(log k)
were also calculated from the data obtained with the calibration mixture and, therewith, log Koc of the test substance was determined from its measured capacity factor.
Finally, solutions of the reference substances were injected individually to confirm the peak assignment. - Details on test conditions:
- Equipment
Perkin Elmer (series 200) HPLC system comprising:
- high pressure pump
- auto-sampler
- column compartment
- refractive index detector
Column - 250mm x 4.6mm, Nucleodur® 100-5 CN-RP (Macherey-Nagel)
Mobile phase: methanol / water 55/45 (v/v))
Flow rate: 1.0 ml/min
Column temp: 35°C
Injected volume: 100 µl - Type:
- log Koc
- Value:
- 3.41
- Temp.:
- 35 °C
- Matrix:
- HPLC approach (OECD 121)
- Remarks on result:
- other: Peak 3 - minor component (5.4% of surface area)
- Type:
- log Koc
- Value:
- 2.89
- Temp.:
- 35 °C
- Matrix:
- HPLC approach (OECD 121)
- Remarks on result:
- other: Peak 1 - minor component (2.5% by surface area)
- Key result
- Type:
- log Koc
- Value:
- 3.14
- Temp.:
- 35 °C
- Matrix:
- HPLC approach (OECD 121)
- Remarks on result:
- other: Peak 2 - major component (92.1% by surface area)
- Details on results (HPLC method):
- Detailed results are given in appendix 1 and illustrated by the graph in appendix 2 of the attached study report.
The chromatograms of GR-50-1408 show three peaks at average retention times of 5.28 minutes (~2.5% peak area, can be assigned to non-cyclopropanates products present in the batch tested); the main peak 5.76 minutes (~92.1% peak area) and 6.45 minutes (~5.4% peak area) corresponding to adsorption coefficients (log value) of 2.89, 3,14 and 3.41.
Therefore Adsorption coefficient of (Koc) of GR-50-1408:
Log Koc = 3.14 - Validity criteria fulfilled:
- yes
- Conclusions:
- The chromatograms of GR-50-1408 show three peaks at average retention times of 5.28 minutes (~2.5% peak area, can be assigned to non-cyclopropanates products present in the batch tested); the main peak 5.76 minutes (~92.1% peak area) and 6.45 minutes (~5.4% peak area) corresponding to adsorption coefficients (log value) of 2.89, 3,14 and 3.41.
Therefore Adsorption coefficient of (Koc) of GR-50-1408:
Log Koc = 3.14 / Koc = 1380 - Executive summary:
The adsorption coefficient of (Koc) on soil and on sewage sludge of GR-50-1408 was determined by the Reverse Phase High Performance Liquid Chromatographic Method according to the OECD Guidelines for Testing of Chemicals Method No 121.
The result is:
Adsorption coefficient of (Koc) of GR-50-1408:
Log Koc = 3.14
Reference
Description of key information
The adsorption coefficient of (Koc) on soil and on sewage sludge of GR-50-1408 was determined by the Reverse Phase High Performance Liquid Chromatographic Method according to the OECD Guidelines for Testing of Chemicals Method No 121.
The result is:
Adsorption coefficient of (Koc) of GR-50-1408:
Log Koc = 3.14 / Koc = 1380
Key value for chemical safety assessment
- Koc at 20 °C:
- 1 380
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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