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EC number: 274-569-0 | CAS number: 70321-85-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
ACUTE ORAL TOXICITY:
A study was carried out equivalent or similar to EU Method B.1 and OECD Guideline 401 (Acute oral toxicity). The acute oral median lethal dose (LD50) of the test item in the rat was found to be > 5000 mg/kg.
ACUTE DERMAL TOXICITY:
A study was carried out according to EU Method B.3 and OECD Guideline 402 (Acute dermal toxicity). The acute dermal median lethal dose (LD50) of the test item in the rat was found to be > 2000 mg/kg.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March - April 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: guideline study, non-GLP
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Bantin and Kingman, Grimston, Aldbrough, Nr. Hull, HUll 4QE
- Age at study initiation: no data
- Weight at study initiation: 125-225 g
- Fasting period before study: overnight before treatment
- Housing: gang housing in groups of 2 or 5 by sex as appropriate in grid floor polypropylene boxes
- Diet (e.g. ad libitum): Rat and Mouse No. 1 Expanded Diet, BP Nutrition (U.K.) Ltd., Witham, Essex
- Water (e.g. ad libitum): tap water
- Acclimation period: 3 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 25°C
- Humidity (%): 19 - 25°C
- Photoperiod (hrs dark / hrs light): natural lighting conditions - Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- - Pre-test: 10, 50, 500, 5'000 and 15'000 mg/kg
- Main study: 5000 mg/kg - No. of animals per sex per dose:
- - Pre-test: 1 male / 1 female per dose group
- Main study: 5 males / 5 females - Control animals:
- no
- Preliminary study:
- 100% mortality was observed at 15'000 mg/kg in the pre-test only.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed in main study.
- Clinical signs:
- other: None reported.
- Gross pathology:
- None reported.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 on Wistar rats was found to be > 5000 m/kg (males/females).
- Executive summary:
The acute oral toxicity on Wistar rats was assessed in a study equivalent or similar to OECD testing method no. 401. A range-finding test with reduced number of animals and dose groups of 10-15'000 mg/kg was performed, followed by the main study with a limit dose of 5000 mg/kg bw.
Neither mortality nor signs of toxicity were observed in the main study. In conclusion, the acute oral LD50 on Wistar rats was determined to be > 5000 mg/kg.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- March 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-compliant guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Nossan S.r.I., Correzzana (MI), Italy
- Age at study initiation: 6-8 weeks
- Weight at study initiation: 176-200 g
- Housing: individually in polycarbonate cages
- Diet (e.g. ad libitum): commercially available laboratory rodent diet (Altromin MT, A. Rieper S.p.A., Bolzano, Italy)
- Water (e.g. ad libitum): tap water
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24°C
- Humidity (%): 45-65%
- Photoperiod (hrs dark / hrs light): artificial cycle of 12 hours light and 12 hours dark each day - Type of coverage:
- semiocclusive
- Vehicle:
- water
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred following dosing.
- Clinical signs:
- other: No clinical signs were observed, with the exception of an abrasion, which became a scab, observed in a single female animal on Days 2, 3 and 4. This sign was not considered to be related to treatment with the test substance.
- Other findings:
- No abnormalities were found on necropsy of animals on termination of the study.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermall LD50 on Sprague-Dawley rats was found to be > 2000 m/kg (males/females).
- Executive summary:
The acute dermal toxicity on Sprague-Dawley rats was assessed in a study following OECD testing method no. 403. A limit test with a dose of 5000 mg/kg bw was performed. Neither mortality nor signs of toxicity were observed in the main study. In conclusion, the acute oral LD50 on rats was determined to be > 2000 mg/kg.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Source: GLP-reports
Justification for selection of acute toxicity – oral endpoint
non-GLP study following OECD-guideline; Klimisch 2
Justification for selection of acute toxicity – dermal endpoint
GLP study following OECD-guideline; Klimisch 1
Justification for classification or non-classification
Based on the data available the substance is not classified according to Regulation 1272/2008/EEC (CLP) and according to Directive 67/548/EEC (DSD).
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