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Diss Factsheets
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EC number: 248-704-9 | CAS number: 27871-49-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- Serious reporting deficiencies, both in terms of methods and results (e.g., inoculum, blanks, replicates, test conditions not reported); spacing of sampling times unsuitable for determining ready biodegradability (BOD determination only after 5 and 28 days); see further below for details.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method C.5 (Degradation: Biochemical Oxygen Demand)
- Deviations:
- not specified
- Remarks:
- It is furthermore not clear which method was used for the test substance (EU C.5 or OECD 301D).
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- yes
- Remarks:
- Sampling only on day 5 and 28; no inoculum blank, abiotic control, toxicity control, replication and corresponding variability reported; no information on primary analytical parameter; no information on inoculum and test conditions.
- GLP compliance:
- not specified
- Oxygen conditions:
- not specified
- Inoculum or test system:
- not specified
- Details on inoculum:
- No data
- Duration of test (contact time):
- ca. 28 d
- Initial conc.:
- 2.04 mg/L
- Based on:
- test mat.
- Initial conc.:
- ca. 1.38 mg/L
- Based on:
- ThOD/L
- Parameter followed for biodegradation estimation:
- other: BOD (biochemical oxygen demand)
- Details on study design:
- No data
- Reference substance:
- acetic acid, sodium salt
- Reference substance:
- other: mixture of glucose and glutamic acid, depending on the guideline used (not differentiated among a series of lactate esters)
- Parameter:
- other: % degradation based on BOD
- Value:
- ca. 15
- Sampling time:
- 5 d
- Key result
- Parameter:
- other: % degradation based on BOD
- Value:
- ca. 76
- Sampling time:
- 28 d
- Parameter:
- BOD5
- Value:
- >= 0.21 - <= 1.05 g O2/g test mat.
- Results with reference substance:
- Complete degradation within five days.
- Validity criteria fulfilled:
- no
- Remarks:
- Reporting insufficient for evaluating validity.
- Interpretation of results:
- readily biodegradable
- Remarks:
- Data insufficient for definitive evaluation of biodegradability.
- Conclusions:
- The substance is biodegradable within the 28-d test period. However, due to considerable reporting deficiencies, a final conclusion on biodegradability is not possible (10-d window not evaluable).
- Executive summary:
Several esters of lactic acid were tested for ready biodegradability and/or biochemical oxygen demand according to OECD 301D (closed bottle test), however with significant methodological and reporting deficiencies. Alloction of test methods to substance is neither evident from the materials and methods section nor from the results section.Therefore, study performance and documentation are considered unreliable. Nevertheless, the results indicate that methyl (S)-lactate may be readily biodegradable, but data allowing evaluation of the 10-d window are missing.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- Validated QSAR model, acceptable in a regulatory context.
- Justification for type of information:
- QSAR prediction
1. SOFTWARE
EpiSuite 4.11
2. MODEL (incl. version number)
BIOWIN v4.11
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
SMILES: OC(C)C(=O)OC
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
See attached QMRF.
5. APPLICABILITY DOMAIN
See attached QMRF.
6. ADEQUACY OF THE RESULT
Ready biodegradability is a key parameter for the environmental risk assessment and for classification for environmental hazards. - Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on information requirements and chemical safety assessment, chapter R.6: QSARs and grouping of chemicals, May 2008.
- Principles of method if other than guideline:
- (Q)SAR calculation
- GLP compliance:
- no
- Key result
- Parameter:
- probability of ready biodegradability (QSAR/QSPR)
- Remarks on result:
- readily biodegradable based on QSAR/QSPR prediction
- Details on results:
- Biowin1 (Linear Biodeg Probability) 1.0309
Biowin2 (Non-Linear Biodeg Probability) 0.9988
A Probability Greater Than or Equal to 0.5 indicates --> Biodegrades Fast
A Probability Less Than 0.5 indicates --> Does NOT Biodegrade Fast
Biowin3 (Survey Model - Ultimate Biodeg) 3.2693
Biowin4 (Survey Model - Primary Biodeg) 4.0559
Result Classification: 5.00 -> hours 4.00 -> days 3.00 -> weeks
(Primary & Ultimate) 2.00 -> months 1.00 -> longer
Biowin5 (MITI Linear Biodeg Probability) 0.7730
Biowin6 (MITI Non-Linear Biodeg Probability) 0.9115
A Probability Greater Than or Equal to 0.5 indicates --> Readily Degradable
A Probability Less Than 0.5 indicates --> NOT Readily Degradable
Biowin7 (Anaerobic Linear Biodeg Prob) 0.8157
A Probability Greater Than or Equal to 0.5 indicates --> Biodegrades Fast
A Probability Less Than 0.5 indicates --> Does NOT Biodegrade Fast
The prediction is not dependent on stereochemistry. - Validity criteria fulfilled:
- not applicable
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Methyl (S)-lactate is predicted to be readily biodegradable by the (Q)SAR model BIOWIN v4.11.
- Executive summary:
Methyl (S)-lactate is predicted to be readily biodegradable by the (Q)SAR model BIOWIN v4.11.
Referenceopen allclose all
Description of key information
Methyl (S)-lactate is readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
According to QSAR modelling, the substance is readily biodegradable. This was also shown in an experimental study from Bowmer (1998), though having deficiencies regarding reporting.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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