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EC number: 231-293-5 | CAS number: 7486-38-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Based on the absence of data for disodium adipate, results from the corresponding acid are taken into account for this endpoint. In a test of adipic acid with fish (Danio rerio) a LC0 of >=1000 mg/l after 96 hours is obtained. The study was conducted according UBA-Verfahrensvorschlag: "Letale Wirkung beim Zebrabaerbling Brachydanio rerio, LC0, LC50, LC100; 48-96 h" , Mai 1984 (Bayer AG, 1991) in buffered medium. The effect concentrations were confirmed by analytical monitoring.
Key value for chemical safety assessment
Additional information
Based on the absence of data for disodium adipate, a read-across
approach with adipic acid is applied. In aqueous media, disodium adipate
and adipic acid acid dissociate into the corresponding anion
(1,6-hexandioic acid ion) and the sodium ion and hydrogen ion (proton),
respectively. Fate, behavior and the ecotoxicological properties of
adipic acid and its disodium salt are thought to be an effect of the
di-carboxylate ion rather than of the sodium ion or the hydrogen ion
(proton), which are normal constituents in environmental systems and
have no relevant ecotoxic properties in low concentrations.
Therefore a read-across between disodium adipate and adipic acid is
justified.
There are studies on toxicity to fish of lower values for adipic acid available. The studies were discussed in the ICCA OECD/HPV-program as follows.
In a study with adipic acid, conducted according to US-EPA Method 660/3-75-009 a 96 h-LC50 of 97 mg/l for Pimephales promelas was determined. (Mattson, 1976). The authors note that the pH was < 5.9 during the test. In addition, there is no exact information on oxygen content of the test solutions. It is only reported that the oxygen content was not < 4 mg/l. Therefore, it cannot be excluded that the toxicity observed was due to pH effects and possibly oxygen limitations. A reliability score of 3 (invalid) was assigned and the study should not be used for the hazard assessment of adipic acid.
In another acute test performed with Leuciscus idus according to the German national standard method DIN 38412 Part 15 a 96 h-LC50 of 230 mg/l for adipic acid was obtained (BASF, 1980). Also in this study the pH of the test solutions was in the range of 3.8 to 7. For the concentration 215 mg/l that is in the same order of magnitude with the LC50 the pH was between 4.3 and 4.7 and therefore pH related effects cannot be excluded. Additionally, a test at a concentration of 464 mg/l in neutralised test solution was carried out. The exposure duration was not reported. No effects were observed. For this reason also this study should not be used for the hazard assessment.
Further, lower values on toxicity of adipic acid to fish are found for the species Oryzias latipes (MITI, 1997). First, a 96h-LC50 > 100 mg/l conducted according to OECD TG 204 “Fish, Acute Toxicity Test” is reported. Second, a 14d-LC50 of 80 mg/l is obtained following the OECD TG 204 “Fish, Prolonged Toxicity Test: 14-day-Study”. As no information is given on pH, the studies are stated to be reliable, but should not used for the hazard assessment, based on the given reasons resulting from the discussion above.
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