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Diss Factsheets
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EC number: 406-040-9 | CAS number: 125643-61-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Information of uptake and metabolism after oral application was obtained from a study in rats (Huntington, 2006), wheras information on absorption through the skin was obtained from a study in mice (Huntington, 2006). Both studies were performed under GLP and according to OECD testing guidelines 417 and 427, respectively. 14C-labelled substance was used for tracing.
Upon single oral dosing, a total of 3 metabolites in the freshly prepared urine pools of animals treated with 50 mg/kg bw were identified via molecular weight and fragmentation pattern using a mass spectrometer operating in the negative electrospray mode (ESI LC/MS). Metabolites in the other urine and fecal fractions were correlated to these identified metabolites via their retention times. Upon sacrifice after 7 days, less than 0.3% radioactivity were detected in tissues at 0.5 and 50 mg/kg bw, respectively.
Upon single dermal exposure, the absorption rate was calculated to be 4.42 % at 6 h (The absorbable fraction of test substance was calculated as the sum of excreta, tissues, treated skin after stripping and stratum corneum in percent of applied radioactivity.) Mean tissue concentrations of radioactivity in carcass, gastrointestinal tract and treated skin corresponded to 2.26%, 0.03% and 0.07% of applied dose.
Based on the experimental data, the substance is considered to be non bioaccumulating.
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