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EC number: 217-285-4 | CAS number: 1798-60-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted according to an internal BASF Test method, which in principle was similar to OECD TG 401; GLP was not compulsory at the time the study was conducted.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- The study was conducted according to a BASF Testing method, which in principle was similar to the OECD TG 401.
- GLP compliance:
- no
- Remarks:
- GLP was not compulsory at the time the study was conducted
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- (R)-1-hydroxy-1-phenylacetone
- EC Number:
- 217-285-4
- EC Name:
- (R)-1-hydroxy-1-phenylacetone
- Cas Number:
- 1798-60-3
- Molecular formula:
- C9H10O2
- IUPAC Name:
- (1R)-1-hydroxy-1-phenylpropan-2-one
- Details on test material:
- - Name of test material (as cited in study report): (-)-Phenylacetylcarbinol
- Physical state: liquid
- Analytical purity: 67.4 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Willi Gassner, Sulzfeld
- Age at study initiation: about 12 weeks
- Weight at study initiation: 150 g (females, mean weight), 175 g (males, mean weight)
- Fasting period before study: 16 hrs
- Housing: 5 animals/cage, steel wire-mesh cages (FA. Becker & Co., Castrop-Rauxel)
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20- 26
- Humidity (%): 45- 75
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- (0.5 % in aqueous solution)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 46.4, 31.6, 21.5, 14.7, 10.0 % (g/v) for doses 4640, 3160, 2150, 1470 and 1000 mg/kg bw
- Amount of vehicle (if gavage): 10 mL/kg bw
- Justification for choice of vehicle: equivalent to physiological medium - Doses:
- 1000, 1470, 2150, 3160, 4640 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: shortly before study, between day 2 and 4, day 7, day 13 after application
- Frequency of observations: immediately after substance application (< 15 min), 15, 30, 60, 120, 240, 300 min after substance application, afterwards check for clinical symptoms once per workday. Twice daily on workdays and once on other days check for dead and moribund animals.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 470 - < 2 150 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1000 mg/kg bw: 0/5 females and 0/5 males died
1470 mk/kg bw: 0/5 males and 2/5 females (at 2 d post-dose) died
2150 mg/kg bw: 4/5 males (at 1 d post-dose), 4/5 females (at 1 d post-dose) died
3160 mg/kg bw: 5/5 males (at 1- 48 hrs post-dose), 5/5 females (at 1- 48 hrs post-dose) died
4640 mg/kg bw: 5/5 males (at 1- 24 hrs post-dose), 5/5 females (at 1- 24 hrs post-dose) died - Clinical signs:
- other: 1000 mg/kg bw: dyspnoea, apathy, abnormal position, staggering, atony, unusual pain reflex, unusual corneal reaction, narcotic state, ruffled fur, erythema, exsiccosis, bad general state 1470 mg/kg bw: dyspnoea, apathy, abnormal position, staggering, aton
- Gross pathology:
- sacrificed animals: no findings
dead animals:
- in heart: acute dilatation of ante-chamber, acute congestive hyperaemia
- stomach: atonic liquid stomach content
Any other information on results incl. tables
Table 1. Table for acute oral toxicity.
|
|||
Dose |
Toxicological results* |
Time of death |
Mortality (%) |
Males |
|||
1000 |
0/5 |
--- |
0 |
1470 |
0/5 |
--- |
0 |
2150 |
4/5 |
Day 1 |
80 |
3160 |
5/5 |
1 hr, day 1, day 2 |
100 |
4640 |
5/5 |
1hr, Day 1 |
100 |
|
|
|
|
|
|
|
|
Females |
|||
1000 |
0/5 |
--- |
0 |
1470 |
2/5 |
day 2 |
40 |
2150 |
4/5 |
day 1 |
80 |
3160 |
5/5 |
1 hr, day 1, day 2 |
100 |
4640 |
5/5 |
1hr, Day 1 |
100 |
* first number = number of dead animals |
|
||
second number = number of animals used |
Table 2: Mean body weights (g) of surviving male and female rats over 14 days of observation |
|||||
Males |
|||||
Doses (mg/kg bw) |
4640 |
3160 |
2150 |
1470 |
1000 |
Initially |
170 |
170 |
180 |
180 |
180 |
Day 2 to 4 |
n.a.* |
n.a. |
184 |
197 |
212 |
Day 7 |
n.a. |
n.a. |
217 |
237 |
244 |
Day 13 |
n.a. |
n.a. |
258 |
272 |
270 |
Females |
|||||
Doses (mg/kg bw) |
4640 |
3160 |
2150 |
1470 |
1000 |
Initially |
150 |
150 |
150 |
150 |
150 |
Day 2 to 4 |
n.a.* |
n.a. |
169 |
157 |
176 |
Day 7 |
n.a. |
n.a. |
182 |
185 |
188 |
Day 13 |
n.a. |
n.a. |
193 |
201 |
200 |
* not applicable because of 100% mortality |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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